DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and cyk-3

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001022992.1	Gene:	cyk-3 / 175853	WormBaseID:	WBGene00000874	Length:	1178	Species:	Caenorhabditis elegans

Alignment Length:	1102	Identity:	210/1102 - (19%)
Similarity:	324/1102 - (29%)	Gaps:	502/1102 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 TQYARLGLITCQDLYRRMQEKSVLVMDCRPSADYEASHLTYYCAFNVPEELITPGMSAGRLQARL 205
            :|.||:..:.|..|.                :|.|.|::  |...|||||..|         ...
Worm   217 SQLARIWDVDCDKLL----------------SDEELSNM--YKDLNVPEEHQT---------VTK 254

  Fly   206 SSSAKAS------WASRSVKDSVVLMDWNTKDAQPATNTAISTLLDI------------------ 246
            ||:.|::      ||..:.|               ..|...|..|.|
Worm   255 SSNGKSALVDFGIWAQENEK---------------YVNEYYSMALQIGHICLGLRPESRKMELQI 304

  Fly   247 ------------LKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDI 299
                        |..|:          ||..|:...:..:.....||:   |..|:....|.:|
Worm   305 VNEFEKRASELPLSEWN----------IVASGWHAELRSFLEADKNPN---PIDNSGIKGTRED- 355

  Fly   300 EYPSIHDITMK-EDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQR 363
                  ..|.| ..|||:..|.:||.          :....|..|.|               |.|
Worm   356 ------SWTSKVACISAESARLKPDL----------IPSDYIRVPVP---------------LWR 389

  Fly   364 AEQNDEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQEL- 427
            |             |.|    ..|...|.|.:...:.|..|      ..|:|:...||..::.|
Worm   390 A-------------WLR----WHGCALTVDSQFTRKYLDGE------FFEDNKPALELYPLEILL 431

  Fly   428 --HNVTQQLSQKEVEAT-RNIES----KIRERQRLDEQHELERQERE------RLLAIARETKKH 479
              |:  ::.||...|.| |::.|    ::.....:||...|.:.|..      ||..:.:|
Worm   432 LGHD--RKKSQDGTENTPRSLTSWACAQVSRSMTVDELLALCKTELRLGDGDARLWQVVKE---- 490

  Fly   480 YKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNK----AEIPTFDRAMKPQPRNV 540
                          |.|...::.|..::|.||......|...||    .|:......:.|:....
Worm   491 --------------NEEGNVLLDDGAQNLHQLYSSLGKTKKVNKMKLLLEVRERGTGVWPEELRA 541

  Fly   541 ERTSQRVRDFSPV-----IGQNVGR-GLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNY 599
            ..:.:::...|.:     :..:.|| |..||.|.||.||.|:.:|||:....||:|.:.:...:.
Worm   542 SLSGKQITAASTLSSNAQLSDSSGRPGAVGLVNYGNFCYRNAGIQCLARVSPLTQYFLDEDNLDA 606

  Fly   600 ISRSNKTNGQVIE---EVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILM 661
            |.|.|...|...|   |.|.|::|:|..:.|.:|..|....:.....:|...:|.|..||:..|:
Worm   607 IKRGNLRRGDAAETTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVAFLL 671

  Fly   662 DWLHSDL----QTLH-VPRQREMISA---------------------SEKAWLEFTKAKESMILH 700
            |.||:.:    ::|| .|.:.|...:                     :|::|.|:.|..||::..
Worm   672 DQLHTSMYESNKSLHPSPEESEGTDSNKLSDSSKKKEADKEEADEEKAERSWTEYEKQNESLVTQ 736

  Fly   701 LFYGQMKSTVKCVACHKESATYESFSNLSL---------------------------ELPPNSNV 738
            ||.||::|.:.|..|...|:.:|.|::|||                           .|..:|.|
Worm   737 LFTGQLRSRLICRTCQSSSSVFEPFTSLSLPIGFEDVDLYQVIVVHRDGRIPRRYGFRLSRDSKV 801

  Fly   739 CQLN----------------QCM------------------------DMYFSGERIHG------- 756
            ..|.                |||                        ..:.||.|::.
Worm   802 GNLREVVAVSSGISMSHLTIQCMSSKGTLMSRSPNHRSSNLRDELPLSSFPSGARLYALELPEST 866

  Fly   757 ----------------------------------------------------------------- 756

Worm   867 GEDQWRVAMHRKLQYNHEPYILGSTAGFIVSRFGLPLIVGLDEEVTGKKLYEDVMYQMHRFMEHS 931

  Fly   757 -------------------------------W--------------------------NCP---- 760
                                           |                          |||
Worm   932 VNSSSSRAHDPCEDENSGYPFTLCLVDPNYEWCGQCPALRFCRGCPIRPDESKVFIPANCPIAVD 996

  Fly   761 --------------------------------------------SC---------------KTKR 766
                                                        ||               ||.|
Worm   997 WLPIALYLRYNHSQEQACEDDPSVAETWSRHFAPSSLEHCIEKFSCPETLDAAIQCDRCEKKTMR 1061

  Fly   767 DAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYL-------RFPLENLDMNPYIARAESR 824
            |  |.:.|.|||..|::|||||        .::::|..:       .|||::.|..|::.:.:.
Worm  1062 D--KVMTIWKLPKYLIIHLKRF--------EFLREQGRMGKCKRTVNFPLKHFDPAPFVDKPDG- 1115

  Fly   825 AVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
                .||:..|::||||.:..||:.|:.|| |..||...:|..|..:....|....||:|||
Worm  1116 ----NTYECIALANHYGQLSCGHFIAYAKS-NEDKWLLLNDCSVREVSEEEVDKQGAYLLFY 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087	27/165 (16%)
		UCH	562..886	CDD:278850	117/618 (19%)
		Peptidase_C19R	564..887	CDD:239139	119/618 (19%)
cyk-3	NP_001022992.1	EFh_PEF	23..201	CDD:330173
		EF-hand_7	177..241	CDD:316058	8/41 (20%)
		Peptidase_C19	322..1175	CDD:321984	183/945 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940