DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and Usp15

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_006241493.1	Gene:	Usp15 / 171329	RGDID:	628795	Length:	981	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	182/837 - (21%)
Similarity:	266/837 - (31%)	Gaps:	384/837 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 QDYIVENNRLREELSRIQELHN------VTQQLSQKEVEATRNIESKIRERQRLDEQHELERQER 466
            |...|::.::...|:.::...|      ||::.|:.:...|  ||.:||:...:.::.|
  Rat   120 QGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDT--IEKEIRKIFNIPDEKE------ 176

  Fly   467 ERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGD---PDPTIAPNKAEIPT 528
                  ||...| |.|.|......|...::|..:....:..:.|...|   |....||.......
  Rat   177 ------ARLWNK-YMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSAPKSPGASN 234

  Fly   529 FDRAMKPQP------------RNVER--------TSQRVRDFSPVIGQNVGRGLTGLKNLGNTCY 573
            |....|..|            |||:.        |:.:..|:|.....|...||.||.||||||:
  Rat   235 FSTLPKISPSSLSNNYNNINNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCF 299

  Fly   574 MNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRDLRY 636
            |||.:|||||||.||||.::|||:..::..|.  ..|::.:..|.|||::|:|::..|..|..:.
  Rat   300 MNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKT 364

  Fly   637 VVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS-----------ASEKAWLEF 690
            .||::...|.|..|||..|.|..|:|.||.||..:   |::..|.           .:|:||...
  Rat   365 QVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKPYIQLKDADGRPDKVVAEEAWENH 426

  Fly   691 TKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP---------------------- 733
            .|..:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||
  Rat   427 LKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERSLEVYLVRMDPLAKPMQ 491

  Fly   734 ----------------------------------------------------------------- 733

  Rat   492 YKVIVPKIGNILDLCTALSALSGVPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEINI 556

  Fly   734 ----------------------------------------------------------------- 733

  Rat   557 NRTEDTEHVVIPVCLREKFRHSSYTHHTGSSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKMS 621

  Fly   734 ----------------------PN----------------------------------------- 735
                                  ||
  Rat   622 TETEETDGPLRCCEDQNINGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDSVGG 686

  Fly   736 -----SNVC-------------------------------------------------------- 739
                 :.:|
  Rat   687 DNDSENGLCTEETCKGQLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFLAL 751

  Fly   740 -----------------------------------QLNQCMDMYFSGERIHG---WNCPSCKTKR 766
                                               :|..|::::.:.|::..   |.||:||..:
  Rat   752 DWDPDLKKRYFDENAAEDFEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQ 816

  Fly   767 DAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARAESRAVTPK 829
            .|.||||:..||||||||||||     :...||  |....:.||:.:|||:.::....:   .|.
  Rat   817 QATKKLDLWSLPPVLVVHLKRF-----SYSRYMRDKLDTLVDFPISDLDMSEFLINPNA---GPC 873

  Fly   830 TYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            .|.|.|||||||.|.|||||||.|:.:.|||:.|||..||......:||.|||:|||
  Rat   874 RYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	143/652 (22%)
		Peptidase_C19R	564..887	CDD:239139	144/652 (22%)
Usp15	XP_006241493.1	UBP12	12..932	CDD:227847	182/837 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910