Protein Alignment Usp8 and Usp15

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_081880.2
• Gene: Usp15 / 14479
• MGIID: 101857
• Length: 981
• Species: Mus musculus
• Alignment Length: 840
• Identity: 177/840 - (21%)
• Similarity: 267/840 - (31%)
• Gaps: 396/840 - (47%)

  Fly   406 KAQDYIVE---------NNRLREELSRIQELHNVTQQLSQKEVEATRNI----ESKIRERQRLDE 457
            |.:.|:.|         ||.:....|:...:..:     :||:....||    |:::..:...:.
Mouse   128 KVEVYLTELKLCENGNMNNVVTRRFSKADTIDTI-----EKEIRKIFNIPDEKEARLWNKYMSNT 187

  Fly   458 QHELERQE---------RERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTG 513
            ...|.:.:         :.::|.|.::.:.......||.|.|||         :.:..:|
Mouse   188 FEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPG---------ASNFSTL----- 238

  Fly   514 DPDPTIAPNKAEIPTFDRAMKPQPRNVER--------TSQRVRDFSPVIGQNVGRGLTGLKNLGN 570
               |.|:|:...    :.......|||:.        |:.:..|:|.....|...||.||.||||
Mouse   239 ---PKISPSSLS----NNYNNINNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGN 296

  Fly   571 TCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRD 633
            ||:|||.:|||||||.||||.::|||:..::..|.  ..|::.:..|.|||::|:|::..|..|.
Mouse   297 TCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRA 361

  Fly   634 LRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS-----------ASEKAW 687
            .:..||::...|.|..|||..|.|..|:|.||.||..:   |::..|.           .:|:||
Mouse   362 FKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKPYIQLKDADGRPDKVVAEEAW 423

  Fly   688 LEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP------------------- 733
            ....|..:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||
Mouse   424 ENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERSLEVYLVRMDPLAK 488

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Mouse   489 PMQYKVIVPKIGNILDLCTALSALSGVPADKMIVTDIYNHRFHRIFAVDENLSSIMERDDIYVFE 553

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Mouse   554 ININRAEDTEHVVIPVCLREKFRHSSYTHHTGSSLFGQPFLMAIPRNNTEDKLYNLLLLRMCRYV 618

  Fly   734 -------------------------PN-------------------------------------- 735
                                     ||
Mouse   619 KMSTETEETDGHLRCCEDQNINGNGPNGLHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDS 683

  Fly   736 --------SNVC----------------------------------------------------- 739
                    :.:|
Mouse   684 VGGDNDSENGLCTEETCKGQLTGHKKRLFTFQFNNLGNNDINYIKDDTSHIRFDDRQLRLDERSF 748

  Fly   740 --------------------------------------QLNQCMDMYFSGERIHG---WNCPSCK 763
                                                  :|..|::::.:.|::..   |.||:||
Mouse   749 LALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCK 813

  Fly   764 TKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARAESRAV 826
            ..:.|.||||:..||||||||||||     :...||  |....:.||:.:|||:.::....:
Mouse   814 EHQQATKKLDLWSLPPVLVVHLKRF-----SYSRYMRDKLDTLVDFPISDLDMSEFLINPNA--- 870

  Fly   827 TPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            .|..|.|.|||||||.|.|||||||.|:.:.|||:.|||..||......:||.|||:|||
Mouse   871 GPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809	21/126 (17%)
		Peptidase_C19R	564..887	CDD:239139	144/652 (22%)
Usp15	NP_081880.2	Mediates interaction with SART3. /evidence=ECO:0000250|UniProtKB:Q9Y4E8	2..223		14/99 (14%)
		UBP12	12..932	CDD:227847	177/840 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..237		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..694		2/60 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	952..981