DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usp8 and Usp15

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_081880.2 Gene:Usp15 / 14479 MGIID:101857 Length:981 Species:Mus musculus


Alignment Length:840 Identity:177/840 - (21%)
Similarity:267/840 - (31%) Gaps:396/840 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   406 KAQDYIVE---------NNRLREELSRIQELHNVTQQLSQKEVEATRNI----ESKIRERQRLDE 457
            |.:.|:.|         ||.:....|:...:..:     :||:....||    |:::..:...:.
Mouse   128 KVEVYLTELKLCENGNMNNVVTRRFSKADTIDTI-----EKEIRKIFNIPDEKEARLWNKYMSNT 187

  Fly   458 QHELERQE---------RERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTG 513
            ...|.:.:         :.::|.|.::.:.......||.|.|||         :.:..:|     
Mouse   188 FEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPG---------ASNFSTL----- 238

  Fly   514 DPDPTIAPNKAEIPTFDRAMKPQPRNVER--------TSQRVRDFSPVIGQNVGRGLTGLKNLGN 570
               |.|:|:...    :.......|||:.        |:.:..|:|.....|...||.||.||||
Mouse   239 ---PKISPSSLS----NNYNNINNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGN 296

  Fly   571 TCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKCVASRD 633
            ||:|||.:|||||||.||||.::|||:..::..|.  ..|::.:..|.|||::|:|::..|..|.
Mouse   297 TCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRA 361

  Fly   634 LRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS-----------ASEKAW 687
            .:..||::...|.|..|||..|.|..|:|.||.||..:   |::..|.           .:|:||
Mouse   362 FKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKPYIQLKDADGRPDKVVAEEAW 423

  Fly   688 LEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP------------------- 733
            ....|..:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||                   
Mouse   424 ENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERSLEVYLVRMDPLAK 488

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Mouse   489 PMQYKVIVPKIGNILDLCTALSALSGVPADKMIVTDIYNHRFHRIFAVDENLSSIMERDDIYVFE 553

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Mouse   554 ININRAEDTEHVVIPVCLREKFRHSSYTHHTGSSLFGQPFLMAIPRNNTEDKLYNLLLLRMCRYV 618

  Fly   734 -------------------------PN-------------------------------------- 735
                                     ||                                      
Mouse   619 KMSTETEETDGHLRCCEDQNINGNGPNGLHEEGSPSEMETDEPDDESSQDQELPSENENSQSEDS 683

  Fly   736 --------SNVC----------------------------------------------------- 739
                    :.:|                                                     
Mouse   684 VGGDNDSENGLCTEETCKGQLTGHKKRLFTFQFNNLGNNDINYIKDDTSHIRFDDRQLRLDERSF 748

  Fly   740 --------------------------------------QLNQCMDMYFSGERIHG---WNCPSCK 763
                                                  :|..|::::.:.|::..   |.||:||
Mouse   749 LALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCK 813

  Fly   764 TKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIARAESRAV 826
            ..:.|.||||:..||||||||||||     :...||  |....:.||:.:|||:.::....:   
Mouse   814 EHQQATKKLDLWSLPPVLVVHLKRF-----SYSRYMRDKLDTLVDFPISDLDMSEFLINPNA--- 870

  Fly   827 TPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY 886
            .|..|.|.|||||||.|.|||||||.|:.:.|||:.|||..||......:||.|||:|||
Mouse   871 GPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 143/652 (22%)
Peptidase_C19R 564..887 CDD:239139 144/652 (22%)
Usp15NP_081880.2 Mediates interaction with SART3. /evidence=ECO:0000250|UniProtKB:Q9Y4E8 2..223 14/99 (14%)
UBP12 12..932 CDD:227847 177/840 (21%)
DUSP 24..121 CDD:197831
Ubiquitin_3 135..222 CDD:291502 12/91 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..237 6/29 (21%)
Peptidase_C19 290..>475 CDD:271592 73/187 (39%)
USP7_C2 491..>597 CDD:291217 0/105 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..694 2/60 (3%)
Peptidase_C19R <784..931 CDD:239139 68/155 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 952..981
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1591
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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