DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and USP43

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_694942.3 Gene:USP43 / 124739 HGNCID:20072 Length:1123 Species:Homo sapiens


Alignment Length:715 Identity:139/715 - (19%)
Similarity:209/715 - (29%) Gaps:372/715 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 PTPSGPPSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRV 547
            |.|:.|.|||.                :....|.|.:     ::|..|.|..|            
Human    67 PVPAAPGSPGE----------------ERPPGPQPQL-----QLPAGDGARPP------------ 98

  Fly   548 RDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIE 612
                         |..||||.||||:||:::||||||..|.|:....:|     |:.....:|.|
Human    99 -------------GAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRY-----RAAPGRAEVTE 145

  Fly   613 EVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQ-TLHVPRQ 676
            ::|||::.||..:|....|.:.:..|.:|...|:|..|.|:.|||..|:|.:|.||: :...|  
Human   146 QLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGP-- 208

  Fly   677 REMISASEKAWLEFTKAKE-------------SMILHLFYGQMKSTVKCVACHKESATYESFSNL 728
                 .|||...|.||..|             |.:...|..|.:|::.|..|.|:|.|::.|..:
Human   209 -----VSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCV 268

  Fly   729 SLELP------------------------------------------------------------ 733
            ||.:|                                                            
Human   269 SLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVAALRKMVAEEGGVPADEVILVELYPSG 333

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
Human   334 FQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGTLSAHPLGLSASPRLAAREGQRFSLSLHSESKV 398

  Fly   734 --------------------------------------------------PNSNV---------- 738
                                                              |..|:          
Human   399 LILFCNLVGSGQQASRFGPPFLIREDRAVSWAQLQQSILSKVRHLMKSEAPVQNLGSLFSIRVVG 463

  Fly   739 ----------------------------------------------------------------- 738
                                                                             
Human   464 LSVACSYLSPKDSRPLCHWAVDRVLHLRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSV 528

  Fly   739 -----------CQLNQCMDMYFSGERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRF- 788
                       |.|::|...|...|::   ..|.||.|:..:..:.||.:..||.:|::||||| 
Human   529 WQQQQAHQQHSCTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFC 593

  Fly   789 -YADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKT---------------------- 830
             ..:..|     |....::|||..|:|.|::|:   |:.:|:.                      
Human   594 QVGERRN-----KLSTLVKFPLSGLNMAPHVAQ---RSTSPEAGLGPWPSWKQPDCLPTSYPLDF 650

  Fly   831 -YQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFY---TWLPP 891
             |.||||.||:|.::||||||:|:::..|:|:.:||..|..|....|.:..||||||   ..:||
Human   651 LYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNSIPP 715

  Fly   892  891
            Human   716  715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 122/626 (19%)
Peptidase_C19R 564..887 CDD:239139 124/628 (20%)
USP43NP_694942.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..102 13/80 (16%)
DUF3628 <36..>107 CDD:289100 17/85 (20%)
Peptidase_C19 <98..>210 CDD:271592 46/148 (31%)
Peptidase_C19 102..>284 CDD:271592 64/193 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..221 7/25 (28%)
Peptidase_C19R <540..708 CDD:239139 57/175 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..886
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 959..1049
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1068..1099
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1868
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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