DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and Usp2

DIOPT Version :10

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_446226.3 Gene:Usp2 / 115771 RGDID:621073 Length:618 Species:Rattus norvegicus


Alignment Length:626 Identity:172/626 - (27%)
Similarity:280/626 - (44%) Gaps:112/626 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 ISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKM 377
            :|...|.|||   |...|::....::|        :|:  :..|.....:|:|......|:.|  
  Rat    54 VSPTSFLPRP---RTYGPSSILDCDRG--------RPL--LRSDITGGSKRSESQTRGNERPS-- 103

  Fly   378 WKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRL-------REELSRIQELHNVTQQLS 435
                   |.|||.              .....|.|.:|.|       |::...:.:..:.:|...
  Rat   104 -------GSGLNG--------------GSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDL 147

  Fly   436 QKEVEATRNIES-KIRERQRLDEQHELERQERERLLAIARETKKH-------YKSPTPSGPPSPG 492
            .::..:.|..:| :..:..|..:...::.....|...:|| |:|.       |::.:.|      
  Rat   148 ARDFSSLRTSDSYRTSDGYRASDGFRIDPGNLGRSPMLAR-TRKELCALQGLYQAASRS------ 205

  Fly   493 RNLEDVHVVSDSLE------SLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPR------NVERTSQ 545
                  ..::|.||      |..|:.....|:..|.... ||:    :|..|      |..:.|.
  Rat   206 ------EYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLS-PTY----RPSGRYTLWEKNKGQASG 259

  Fly   546 RVRDFSP---VIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTN 607
            ..|..||   .:.....:||.||:||||||:|||||||||||.:|.:||:...|...:..::..:
  Rat   260 PSRSTSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAH 324

  Fly   608 GQVIEEVAALIKELWNGQYKCVAS-RDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTL 671
            ..::||.|.||:.:|......|.| .:.:..:.:|...|.|.:|||:.|||..|:|.||:::..:
  Rat   325 TALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRV 389

  Fly   672 ------------HVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYES 724
                        |:|.:.:    ..:.|.::.:.::|.|..||.||:||::.|..|...|..::.
  Rat   390 AARPKPSPESLDHLPDEEK----GRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP 450

  Fly   725 FSNLSLELPPNS-NVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHL 785
            |.:|||.:.... ....|..||.::...:.:.|   ..|..|:.::..|||..:.:.|.:||:||
  Rat   451 FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHL 515

  Fly   786 KRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTA 850
            |||......:.   |...::.|||.:||:..:.:...:.||    |.|||||||.||..||||||
  Rat   516 KRFSESRIRTS---KLTTFVNFPLRDLDLREFASENTNHAV----YNLYAVSNHSGTTMGGHYTA 573

  Fly   851 FCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPP 891
            :|:|...|:|..|:|..|:.:.||.|.:|.||:|||....|
  Rat   574 YCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..114 CDD:462647
RHOD 148..278 CDD:444705
Smc <361..>511 CDD:440809 28/170 (16%)
Peptidase_C19R 564..887 CDD:239139 118/339 (35%)
Usp2NP_446226.3 Necessary for interaction with MDM4. /evidence=ECO:0000250|UniProtKB:O75604 1..213 35/207 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 54..112 18/93 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..274 6/27 (22%)
UBP12 <278..>458 CDD:227847 64/183 (35%)
Peptidase_C19R 281..610 CDD:239139 118/339 (35%)
Necessary for interaction with MDM4. /evidence=ECO:0000250|UniProtKB:O75604 416..516 28/99 (28%)
Blue background indicates that the domain is not in the aligned region.

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