DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and Usp2

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_446226.3	Gene:	Usp2 / 115771	RGDID:	621073	Length:	618	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	172/626 - (27%)
Similarity:	280/626 - (44%)	Gaps:	112/626 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 ISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKM 377
            :|...|.|||   |...|::....::|        :|:  :..|.....:|:|......|:.|
  Rat    54 VSPTSFLPRP---RTYGPSSILDCDRG--------RPL--LRSDITGGSKRSESQTRGNERPS-- 103

  Fly   378 WKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRL-------REELSRIQELHNVTQQLS 435
                   |.|||.              .....|.|.:|.|       |::...:.:..:.:|...
  Rat   104 -------GSGLNG--------------GSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDL 147

  Fly   436 QKEVEATRNIES-KIRERQRLDEQHELERQERERLLAIARETKKH-------YKSPTPSGPPSPG 492
            .::..:.|..:| :..:..|..:...::.....|...:|| |:|.       |::.:.|
  Rat   148 ARDFSSLRTSDSYRTSDGYRASDGFRIDPGNLGRSPMLAR-TRKELCALQGLYQAASRS------ 205

  Fly   493 RNLEDVHVVSDSLE------SLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPR------NVERTSQ 545
                  ..::|.||      |..|:.....|:..|.... ||:    :|..|      |..:.|.
  Rat   206 ------EYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLS-PTY----RPSGRYTLWEKNKGQASG 259

  Fly   546 RVRDFSP---VIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTN 607
            ..|..||   .:.....:||.||:||||||:|||||||||||.:|.:||:...|...:..::..:
  Rat   260 PSRSTSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAH 324

  Fly   608 GQVIEEVAALIKELWNGQYKCVAS-RDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTL 671
            ..::||.|.||:.:|......|.| .:.:..:.:|...|.|.:|||:.|||..|:|.||:::..:
  Rat   325 TALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRV 389

  Fly   672 ------------HVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYES 724
                        |:|.:.:    ..:.|.::.:.::|.|..||.||:||::.|..|...|..::.
  Rat   390 AARPKPSPESLDHLPDEEK----GRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP 450

  Fly   725 FSNLSLELPPNS-NVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHL 785
            |.:|||.:.... ....|..||.::...:.:.|   ..|..|:.::..|||..:.:.|.:||:||
  Rat   451 FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHL 515

  Fly   786 KRFYADPSNSGSYMKKQNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTA 850
            |||......:.   |...::.|||.:||:..:.:...:.||    |.|||||||.||..||||||
  Rat   516 KRFSESRIRTS---KLTTFVNFPLRDLDLREFASENTNHAV----YNLYAVSNHSGTTMGGHYTA 573

  Fly   851 FCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWLPP 891
            :|:|...|:|..|:|..|:.:.||.|.:|.||:|||....|
  Rat   574 YCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	118/340 (35%)
		Peptidase_C19R	564..887	CDD:239139	118/339 (35%)
Usp2	NP_446226.3	Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	1..213		35/207 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112		18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..274		6/27 (22%)
		UCH	280..609	CDD:395355	117/339 (35%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	416..516		28/99 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1868
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469048at33208
OrthoFinder	1	1.000	-	-		FOG0000821
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101021
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720