Protein Alignment Usp8 and USP18

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_059110.2
• Gene: USP18 / 11274
• HGNCID: 12616
• Length: 372
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 91/402 - (22%)
• Similarity: 162/402 - (40%)
• Gaps: 81/402 - (20%)

  Fly   518 TIAPNKAEIPTFDRAMKPQPRNVERTSQRVR----DFSPVIGQNVGRGLTGLKNLGNTCYMNSIL 578
            :|....::.|......|.:..|::|...|.|    |:.        .||.||.|:|.||.:||::
Human    14 SILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYP--------HGLVGLHNIGQTCCLNSLI 70

  Fly   579 QCLSNTPQLTEYCISDKYKNYISRSNKTNG------QVIEEVAALIKELWNGQYKCVASRDLRYV 637
            |.         :.::..:...:.|.....|      .|..::..|::::.:.:.|.|...:|.|.
Human    71 QV---------FVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYC 126

  Fly   638 VGQYQK----IFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMI 698
            :   ||    :|   .|.|:.:....|.:.:...:..:|:.   |.:.|     |...:.|:|:|
Human   127 L---QKCNVPLF---VQHDAAQLYLKLWNLIKDQITDVHLV---ERLQA-----LYTIRVKDSLI 177

  Fly   699 LHLFYGQMKSTVKCVACHKESATYESFSNLSLEL--PPNSNVCQLNQCMDMYFSGERIHGWN--- 758
                         ||.|..||:...|...|.|.|  ..:..:..|...:..:|....:...:
Human   178 -------------CVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCF 229

  Fly   759 CPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPYI-ARAE 822
            |.:|..|....:.|.::.||..|.:||.||....|.:   .|..:.|.|| ::||.:..: .:.|
Human   230 CENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQT---RKICHSLYFP-QSLDFSQILPMKRE 290

  Fly   823 SRAVTPKT---YQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVV------- 877
            |.....::   |:|:||..|.|..:.|||..:.::|..||||.|:|..:..:...::.
Human   291 SCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPN 355

  Fly   878 ---SSAAYILFY 886
               ...||:|.|
Human   356 YHWQETAYLLVY 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809
		Peptidase_C19R	564..887	CDD:239139	81/352 (23%)
USP18	NP_059110.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..45		5/25 (20%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	36..51		4/14 (29%)
		Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510	51..112		15/77 (19%)
		UCH	55..367	CDD:425685	80/351 (23%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510	303..312		4/8 (50%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	313..372		14/55 (25%)