Protein Alignment Usp8 and USP19

DIOPT Version :9

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: XP_005264880.1
• Gene: USP19 / 10869
• HGNCID: 12617
• Length: 1423
• Species: Homo sapiens
• Alignment Length: 869
• Identity: 156/869 - (17%)
• Similarity: 228/869 - (26%)
• Gaps: 481/869 - (55%)

  Fly   428 HNVTQQLSQKEVEATRNIESKIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPSPG 492
            |.:|   .|:|..|....:||             .|.|...|.::|..|...:.:|.|
Human   519 HPLT---GQEEARAVEKDKSK-------------ARSEDTGLDSVATRTPMEHVTPKP------- 560

  Fly   493 RNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQN 557
                :.|:.|            |.||     ..:|       |.|.            |||.|.:
Human   561 ----ETHLAS------------PKPT-----CMVP-------PMPH------------SPVSGDS 585

  Fly   558 VGR-----------GLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQ 609
            |..           |.|||.||||||:|||::|.||||.:|.::.....::..|:.:|.  |.|:
Human   586 VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGR 650

  Fly   610 VIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVP 674
            :....|.|::.||.|.:.......|:.:|......|.|..|.|:.||:..|:|.||.||..:...
Human   651 LAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNK 715

  Fly   675 RQREMISA--------SEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLE 731
            ...|.:.:        :|:||.......:|.|:.||.||.||.:.|..|.|.|.|::.|..|.:.
Human   716 PYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVP 780

  Fly   732 LP--------------PNS---------------------------------------------- 736
            ||              |:|
Human   781 LPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHR 845

  Fly   737 ----------------------------------------------------------------- 736
                                                                             
Human   846 VFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKL 910

  Fly   737 -------------NVCQ------------------------------------------------ 740
                         .:||
Human   911 KRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSV 975

  Fly   741 ----------------------------------------------------------------- 740
                                                                             
Human   976 FQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDR 1040

  Fly   741 ----------------------------------------------------------------- 740
                                                                             
Human  1041 GPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNRE 1105

  Fly   741 -----------------------------------------------------------LNQCMD 746
                                                                       |:||::
Human  1106 QRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLN 1170

  Fly   747 MYFSGERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM---KKQNYL 805
            ::...|.:   ..|.||.||..|:|.|:|.:.:||.||:|.||||     :..|::   |..:.:
Human  1171 LFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRF-----SFRSFIWRDKINDLV 1230

  Fly   806 RFPLENLDMNPY-IARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGK-------WFK 862
            .||:.|||::.: |.:.|.:.   .:|.||||.||||.|.||||||..:..|...       |..
Human  1231 EFPVRNLDLSKFCIGQKEEQL---PSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRL 1292

  Fly   863 FDDQVVSALDSSNVVSSAAYILFY 886
            |||..|:.:|.|.||:..||:|||
Human  1293 FDDSTVTTVDESQVVTRYAYVLFY 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	126/722 (17%)
		Peptidase_C19R	564..887	CDD:239139	127/722 (18%)
USP19	XP_005264880.1	p23_like	120..202	CDD:107220
		p23_CS_SGT1_like	391..487	CDD:107223
		USP19_linker	478..600	CDD:293210	27/143 (19%)
		Peptidase_C19	574..>707	CDD:271592	47/151 (31%)
		Peptidase_C19	603..>789	CDD:271592	61/185 (33%)
		USP7_C2	803..>862	CDD:291217	0/58 (0%)
		zf-MYND	896..938	CDD:280009	2/41 (5%)
		Peptidase_C19R	<1160..1317	CDD:239139	62/165 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910