Protein Alignment Usp8 and Usp37

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001414600.1
• Gene: Usp37 / 100361658
• RGDID: 2319715
• Length: 979
• Species: Rattus norvegicus
• Alignment Length: 542
• Identity: 123/542 - (22%)
• Similarity: 216/542 - (39%)
• Gaps: 98/542 - (18%)

  Fly   295 TIDDIEYPSIHDITMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAE 359
            |:.|..:.||..:..|:   |::.|...|....|:..|...:.||    |.....|......|.|
  Rat    75 TLQDNSFLSIDKVPSKD---AEEMRLFLDAVHQNRLHAAMKSSQG----SGSFGTILGSRTSQKE 132

  Fly   360 FLQRAEQNDEQ-------LEKASKMWKR-----------QAAEGDGLNATE--------DQELHF 398
            ..::...:|.|       ||...::..|           :...|.|:..|.        ...|..
  Rat   133 TNRQLSYSDNQASSKRGSLETKDEIPFRKVLGNPGRGPIKTVTGSGMAVTRTIPSLTLTSTPLRT 197

  Fly   399 RILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRNIESKIRERQRLDEQHELER 463
            .:|:..::.:..::..:.|.|:..:    .|.:...::...:.:|...|..||:|.     .|::
  Rat   198 GLLENRTEKRKRMLSGSELTEDYPK----ENDSSSNNKAMTDPSRKYLSSSREKQL-----SLKQ 253

  Fly   464 QERER---LLAIARETKKHYKSPTPSGP-PSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKA 524
            .|..|   ||.:  ::...|.|.|.|.. .|.|.||:..::.:.:..:...|...|.||
  Rat   254 AEENRTPGLLPL--QSSSFYGSRTGSKDYSSGGTNLDRCNISNQTPSAKRSLGFLPQPT------ 310

  Fly   525 EIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRG--------LTGLKNLGNTCYMNSILQCL 581
                        |.:|    :::|......|.|..|.        |.|..|||||||||:|||.|
  Rat   311 ------------PLSV----KKLRCNQDYTGWNKPRAPLSSHQQQLQGFSNLGNTCYMNAILQSL 359

  Fly   582 SNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALI--KELWNGQYKCVASRDLRYVVGQYQKI 644
            .:.....    :|..|..|.........:|...|.|:  |::.|.:.|....:.::..:....:.
  Rat   360 FSLQSFA----NDLLKQSIPWKKIPLNALIRRFANLLIKKDISNSETKKELLKKVKNAISATAER 420

  Fly   645 FRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKA-WLEFTKAKESMILHLFYGQMKS 708
            |.|..|.|:||||:..:|.|..|::.|:...:.|.:...|.: ....||.....::.....:::.
  Rat   421 FSGYVQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVLGEENSPDTSATKVFTCPVITNLEFEVQH 485

  Fly   709 TVKCVACHKESATYESFSNLSLE-------LPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKR 766
            ::.|.||.:.....|.|::||::       |||.|    :...:|::|..|.:. ::|..|..|
  Rat   486 SIICKACGETIPKREQFNDLSIDLPRRKKPLPPRS----IQDSLDLFFRAEELE-YSCEKCGGK- 544

  Fly   767 DAIKKLDISKLPPVLVVHLKRF 788
            .|:.:....:||.||::||||:
  Rat   545 CALVRHKFIRLPRVLILHLKRY 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705
		Smc	<361..>511	CDD:440809	31/179 (17%)
		Peptidase_C19R	564..887	CDD:239139	65/235 (28%)
Usp37	NP_001414600.1	None