DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp8 and USP17L17

DIOPT Version :9

Sequence 1:NP_650948.2 Gene:Usp8 / 42509 FlyBaseID:FBgn0038862 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001243786.1 Gene:USP17L17 / 100287327 HGNCID:44445 Length:530 Species:Homo sapiens


Alignment Length:410 Identity:112/410 - (27%)
Similarity:182/410 - (44%) Gaps:100/410 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   515 PDPTIAP-NKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGL------------TGLK 566
            ||...|. .:..:|      :..|.:.|.......|.:||..|...|..            .||:
Human    25 PDAAFAEIQRTSLP------EKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQ 83

  Fly   567 NLGNTCYMNSILQCLSNTPQLTEYCISDKYKN---------------YISRSNKTNGQVIEEVAA 616
            |:|||||:|:.||||:.||.|..|.:|.::..               :|:|:....|.||:...|
Human    84 NMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQA 148

  Fly   617 LIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS 681
            |......|:                        |:|:||||...:|                   
Human   149 LAAGFHRGK------------------------QEDAHEFLMFTVD------------------- 170

  Fly   682 ASEKAWLEFTK-----AKESMILH-LFYGQMKSTVKCVACHKESATYESFSNLSLELPPNSNVCQ 740
            |.:||.|...|     :|::.::| :|.|..:|.:||:.||..|.|::.:.:::|::....:|  
Human   171 AMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSV-- 233

  Fly   741 LNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYMKKQ 802
             .|.::.....|.::|   ::|..|..:..|.|.|.:.....||::.||||   ...:|:.:.|.
Human   234 -QQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF---SDVTGNKIAKN 294

  Fly   803 NYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYG-TMEGGHYTAFCKSANYGKWFKFDDQ 866
              :::| |.|||.||:::..:   .|..|.||||..|.| :...|||.::.| |..|:|:|.||.
Human   295 --VQYP-ECLDMQPYMSQQNT---GPLVYVLYAVLVHAGWSCHNGHYFSYVK-AQEGQWYKMDDA 352

  Fly   867 VVSALDSSNVVSSAAYILFY 886
            .|:|...::|:|..||:|||
Human   353 EVTAASITSVLSQQAYVLFY 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp8NP_650948.2 USP8_dimer 2..113 CDD:286108
RHOD 148..278 CDD:294087
UCH 562..886 CDD:278850 99/360 (28%)
Peptidase_C19R 564..887 CDD:239139 101/348 (29%)
USP17L17NP_001243786.1 Peptidase_C19E 79..373 CDD:239126 101/350 (29%)
UCH 80..372 CDD:278850 99/347 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..411
HABP4_PAI-RBP1 <426..454 CDD:282609
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..530
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D561804at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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