DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp8 and usp15

DIOPT Version :9

Sequence 1:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_012814096.1	Gene:	usp15 / 100158604	XenbaseID:	XB-GENE-1008519	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	190/911 - (20%)
Similarity:	289/911 - (31%)	Gaps:	419/911 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 KMWKRQAA-------------------EGDG-LNATEDQELHFRILQLESKAQDYIV---EN-NR 416
            |.||:...                   :..| |..|:.|.|...::.    ..|||:   |. |:
Frog    39 KQWKKYVGFDSWDKYQMGDQNVYPGPIDNSGLLKDTDTQSLKEHLID----ELDYILLPTEGWNK 99

  Fly   417 LREELSRIQELHNVTQQLSQK---------EVEATR-------NIESKIRERQRLDEQHELERQE 465
            |....|.::....:.:::.::         ||..|.       |:.:.:..|....:..::..:|
Frog   100 LVSWYSVVESQQPIARKVVEQGMFVKHCKVEVYLTELKLCENGNMNNVVTRRFSKADTIDMIEKE 164

  Fly   466 RERLLAI--ARETK--KHYKSPTPSGPPSPGRNLEDVHVVSDSLESLLQLTGD---PDPTIAPNK 523
            ...:.:|  .:||:  ..|.|.|......|...::|..:....:..:.|...:   |..:: |..
Frog   165 MRTIFSIPDEKETRLWNKYMSNTFEPLNKPESTIQDAGLYQGQMLVIEQKNQEGQWPRGSM-PKS 228

  Fly   524 AEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQN------------------VGR-----GLTGL 565
            :.||.|....|..|.::   |....:|:..|.:|                  .||     ||.||
Frog   229 SGIPNFSTLPKISPSSL---SNNYNNFNSRIMKNSNYCLPSYAAYKNYEYSEPGRHNEQPGLCGL 290

  Fly   566 KNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNK--TNGQVIEEVAALIKELWNGQYKC 628
            .||||||:|||.:|||||||.||||.::|||::.::..|.  ..|::.:..|.|||::|:|:|..
Frog   291 SNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQDELNMDNPLGMRGEIAKSYAELIKQMWSGKYSY 355

  Fly   629 VASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMIS-----------A 682
            |..|..:..||::...|.|..|||..|.|..|:|.||.||..:   |::..|.           .
Frog   356 VTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI---RKKPYIQLKDADGRPDKVV 417

  Fly   683 SEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSNLSLELP-------------- 733
            :|:||....|..:|:|:.:|:|..|||:.|..|.|.|.|::.|..|:|.||
Frog   418 AEEAWENHIKRNDSIIVDIFHGLFKSTLVCPECSKISVTFDPFCYLTLPLPMKKERALEVYLVRM 482

  Fly   734 ----------------------------------------------------------------- 733

Frog   483 DPLAKPMQYKVIVPKIGNIMDLCTALSSLSGIAPEKMVVTDIYNHRFHRIFAMDENLSSIMERDD 547

  Fly   734 ----------------------------------------------------------------- 733

Frog   548 IYVFETSINRTEDTEQVIIPVYLREKFRHTSYSHHHGSTLFGQPFLITVPRNITEDKLYNLLLLR 612

  Fly   734 ------------------------------PN--------------------------------- 735
                                          ||
Frog   613 MCRYVKATNDTEENDGSLHCNKEHTVNGNGPNGIHEEGSPSEMETDEPDDESSQDQELPSENENS 677

  Fly   736 -------------SNVC------------------------------------------------ 739
                         :.:|
Frog   678 QSEDSVGGDNDSENGLCTEDTCKGQSVTGQKKRLFTFQFSNLGSSDITYIKDDTKYIRFDERQLR 742

  Fly   740 --------------------------------------------QLNQCMDMYFSGERIHG---W 757
                                                        :|..|::::.:.|::..   |
Frog   743 LDERSYLALDWDPKLKKKFFDENAAEDFEKHESVDFTPQKKAFMKLKDCIELFTTKEKLGAEDPW 807

  Fly   758 NCPSCKTKRDAIKKLDISKLPPVLVVHLKRFYADPSNSGSYM--KKQNYLRFPLENLDMNPYIAR 820
            .||:||..:.|.||||:..||||||||||||     :...||  |....:.||:.:|||:.::..
Frog   808 YCPNCKEHQQATKKLDLWSLPPVLVVHLKRF-----SYSRYMRDKLDTLVDFPISDLDMSTFLIN 867

  Fly   821 AESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCKSANYGKWFKFDDQVVSALDSSNVVSSAAYILF 885
            ..:   .|..|.|.|||||||.|.|||||||.|:.:.|||:.|||..||......:||.|||:||
Frog   868 PNA---GPCCYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEEQIVSKAAYVLF 929

  Fly   886 Y 886
            |
Frog   930 Y 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	144/653 (22%)
		Peptidase_C19R	564..887	CDD:239139	145/653 (22%)
usp15	XP_012814096.1	UBP12	27..932	CDD:227847	190/911 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940