Protein Alignment Usp8 and usp8

DIOPT Version :10

• Sequence 1: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: XP_002939670.3
• Gene: usp8 / 100124309
• XenbaseID: XB-GENE-969023
• Length: 1059
• Species: Xenopus tropicalis
• Alignment Length: 1076
• Identity: 323/1076 - (30%)
• Similarity: 510/1076 - (47%)
• Gaps: 225/1076 - (20%)

  Fly     5 KKLHMSSNLDDLEKMS-IIPDLRSKGMKILLNTARKLYMTAEEYRLDGDEELAYITYMKYFNMLT 68
            |:|::||:|.||:|.: :.||..|  .|..:::|.|::..|||.||:||||.||:.||||..:..
 Frog     9 KELYLSSSLSDLKKKAEVKPDKTS--TKSYVSSACKIFQKAEECRLEGDEEKAYVFYMKYLFVFE 71

  Fly    69 AIHKKSDYPSHKTTVRQMLGDTESNRRIMDTLEEIINSLRHRYAQ-------------------- 113
            .:.|:||:..::...:.:||.:...:.: :..|::..||::||.:
 Frog    72 LLKKRSDFKQNQDYYKSLLGPSTILKSV-EEAEKLSESLKNRYEEAEVRKKLEERERQEDLKKKE 135

  Fly   114 --------QHQAPEPIAPDLVSNGRAGVDSPITQPTQYARLGLITCQDLYRRMQEK--SVLVMDC 168
                    ....|:|...:.|:..:..|.|...:||.... |.||.:.|:....:.  |:::||.
 Frog   136 GKLFPKDFPEDVPKPNQNETVNGEKNEVLSKRPEPTNVPH-GAITVEKLFEMTNDYNISIIIMDV 199

  Fly   169 RPSADYEASHLTYYCAFNVPEELITPGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDAQ 233
            |.:.|::.||:.  .:.:||||.|.||.::.:::..|..::|..|..|...|.::|:||.:....
 Frog   200 RSTKDFQESHIR--TSISVPEEAIIPGFTSSKIETNLPDTSKEMWNKRGQVDFIILLDWFSSVNN 262

  Fly   234 PATNTAISTLLDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETID- 297
            ....|.:.:|.|.|..|:.....|:...::|||||.:::.||...||..|..|::...:..::.
 Frog   263 LKVGTTLQSLKDALYKWETKTILRSEPLVLEGGYENWLLCYPMFTTNGKVTVPRKRTQESVSLSL 327

  Fly   298 DIEYPSIHD----------ITMKED-------------------ISAKDFRPRPDFNRANKPAAT 333
            |..|||:.:          :.:||.                   :..|| .|.||   |..|.:.
 Frog   328 DFSYPSLEEPALPPPPPPPVCIKESSYEDTINAVKTQKTEEPVHVVQKD-DPVPD---AQTPDSV 388

  Fly   334 RVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKMWKRQAAEGDGL---------- 388
            :|     .:|....|.|.:|        .|.::...::.::|..:|.:|.|...:
 Frog   389 KV-----CQPQKTVKVIPQI--------DRTKKPSVKVTESSSKFKHEAKENQPIQNGRPIPDRS 440

  Fly   389 ------NATEDQELHFRI-LQLESKAQ------DYIVEN------------NRLR--------EE 420
                  ..:...|:|.:. ..::.|.:      |...||            |:.|        :|
 Frog   441 TKPSLDTKSVKSEIHVQFDKNIKEKGEEIKGKVDMHAENNIDNTCAHEEKENKKRNEEKETEMDE 505

  Fly   421 LSRIQELHNVTQQLSQKEVEATRNIESK----------------IRERQRLDEQH---------- 459
            ..|.:||......::.||...|:.:||.                .:|.....::|
 Frog   506 FHRKEELEKKQPVVAGKEPAETKRLESNKPPPDDRKKNGHSSVTPQEPSAHKKEHNSDVTVKDSC 570

  Fly   460 ELERQERERLLAIARE----------------------TKKHYKSPT-----------PSGPPS- 490
            |.:|.:||.|:....|                      |.::|.|||           ||..||
 Frog   571 EDDRPKREPLVRARSEEMGRTVPGMPEGWVKFLEPVTGTYRYYHSPTHTVHMYPPEMAPSSTPST 635

  Fly   491 -PGRNLEDVHVVSD---SLESLLQLTGDPDPTIA----PNKAEIPTFDRAMKP----QPRNVERT 543
             |.:..: |...:|   ....|.:....||.|.|    ..|..:|..:|..||    :....:..
 Frog   636 TPAQKAK-VQATTDIDKEQTKLKRSYSSPDLTQAIKDEDKKKPMPHINRENKPSIVTKAEITKLP 699

  Fly   544 SQRVRDFSPVIGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKT-- 606
            :.::|..:||.| ..|..||||:|||||||||||||||.|||.|.||..::.|:.:|:|||..
 Frog   700 ASKIRSLNPVFG-GAGPALTGLRNLGNTCYMNSILQCLCNTPHLIEYFNNNFYQAHINRSNLLGH 763

  Fly   607 NGQVIEEVAALIKELWNGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTL 671
            .|:|.||...:::.||.||||.::.:|.:..:|:..:.|.|...|||.|.|..|||.||.||...
 Frog   764 KGEVAEEFGCIMRALWTGQYKYISPKDFKITIGKINEQFAGYTHQDSQELLLFLMDGLHEDLNKK 828

  Fly   672 HVPRQREM---------ISASEKAWLEFTKAKESMILHLFYGQMKSTVKCVACHKESATYESFSN 727
            ...|:|:.         ..|::.||.:..:..||:|:.||.||.||||:|:.|.|:|.|:|:|..
 Frog   829 ADNRKRQKEENNDHLSDSQAADSAWYKHKQLNESIIVALFQGQFKSTVQCLTCQKKSRTFEAFMY 893

  Fly   728 LSLELPPNSNVCQLNQCMDMYFSGERI---HGWNCPSCKTKRDAIKKLDISKLPPVLVVHLKRFY 789
            |||.||..|. |.|..|:..:...|::   :.::|.:|||:|.|.||::|.||||:|:||||||
 Frog   894 LSLPLPSTSK-CSLQDCIKAFAKEEKLTDSNRFDCSNCKTQRVATKKIEIWKLPPILLVHLKRF- 956

  Fly   790 ADPSNSGSYMKK-QNYLRFPLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFCK 853
               |..|.:.:| |:|:.||||:||::.|:...::    .|||.|:.||||||.::||||||:||
 Frog   957 ---SFEGRWRQKLQSYVDFPLESLDLSQYVIGPKN----VKTYNLFGVSNHYGGLDGGHYTAYCK 1014

  Fly   854 SANYGKWFKFDDQVVSALDSSNVVSSAAYILFYTWL 889
            :|...:||||||..||.:..|:|.:||||:||||.|
 Frog  1015 NALKQRWFKFDDHDVSEISVSSVKTSAAYMLFYTSL 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647	39/137 (28%)
		RHOD	148..278	CDD:444705	38/131 (29%)
		Smc	<361..>511	CDD:440809	43/256 (17%)
		Peptidase_C19R	564..887	CDD:239139	154/337 (46%)
usp8	XP_002939670.3	USP8_dimer	<30..116	CDD:462647	29/88 (33%)
		RHOD	194..304	CDD:197731	32/111 (29%)
		UBP12	<717..>903	CDD:227847	84/185 (45%)
		Peptidase_C19R	719..1048	CDD:239139	154/337 (46%)