Protein Alignment slmb and BTRC

DIOPT Version :10

• Sequence 1: NP_001262802.1
• Gene: slmb / 42504
• FlyBaseID: FBgn0283468
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_006718117.1
• Gene: BTRC / 8945
• HGNCID: 1144
• Length: 732
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 394/503 - (78%)
• Similarity: 443/503 - (88%)
• Gaps: 7/503 - (1%)

  Fly     4 METDKIMDETN-SNAQAFTTTMLYDPVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSR 67
            |:|:..:.:|. :|.   |::|:....||..:|  |:.|:|||.:||.|||||.||:|||||:|:
Human   227 MKTENCVAKTKLANG---TSSMIVPKQRKLSAS--YEKEKELCVKYFEQWSESDQVEFVEHLISQ 286

  Fly    68 MCHYQHGQINAYLKPMLQRDFITLLPIKGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGML 132
            |||||||.||:||||||||||||.||.:|||||||||||||||:||.::|||||||.||.|:|||
Human   287 MCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGML 351

  Fly   133 WKKLIERKVRTDSLWRGLAERRNWMQYLFKPRPGQ-TQRPHSFHRELFPKIMNDIDSIENNWRTG 196
            |||||||.||||||||||||||.|.|||||.:|.. ...|:||:|.|:|||:.||::||:|||.|
Human   352 WKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCG 416

  Fly   197 RHMLRRINCRSENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDK 261
            ||.|:||:||||.|||||||||||.|||||||||||||||:..|:|.:.|.||||||||||||::
Human   417 RHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER 481

  Fly   262 VIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLR 326
            |||:|||||||||||||||||:||||||||||||||||||||||||||||||||||.||::||||
Human   482 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLR 546

  Fly   327 RVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACLQYRDRLVVSGSS 391
            ||||||||||||||||:|||||||||||||||:||:|||||||||||||||||||||||||||||
Human   547 RVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSS 611

  Fly   392 DNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCLN 456
            ||:||||||||||||||||||||||||||||.|||||||||||||||||||||||||.:.||||.
Human   612 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLR 676

  Fly   457 TLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNFTPNENKTGRTPS 504
            |||||:|||||||||||||||||||||||||||||....:.:..|:||
Human   677 TLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPS 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:463465	29/37 (78%)
		F-box_FBXW1B	85..135	CDD:438954	39/49 (80%)
		WD40	210..488	CDD:238121	251/277 (91%)
		WD40 repeat	213..248	CDD:293791	26/34 (76%)
		WD40 repeat	254..288	CDD:293791	29/33 (88%)
		WD40 repeat	293..330	CDD:293791	33/36 (92%)
		WD40 repeat	337..370	CDD:293791	29/32 (91%)
		WD40 repeat	376..410	CDD:293791	32/33 (97%)
		WD40 repeat	416..459	CDD:293791	37/42 (88%)
		WD40 repeat	465..487	CDD:293791	21/21 (100%)
BTRC	XP_006718117.1	Beta-TrCP_D	266..304	CDD:463465	29/37 (78%)
		F-box_FBXW1A	302..361	CDD:438953	47/58 (81%)
		WD40	430..708	CDD:238121	251/277 (91%)
		WD40 repeat	433..468	CDD:293791	26/34 (76%)
		WD40 repeat	474..508	CDD:293791	29/33 (88%)
		WD40 repeat	513..550	CDD:293791	33/36 (92%)
		WD40 repeat	557..590	CDD:293791	29/32 (91%)
		WD40 repeat	596..630	CDD:293791	32/33 (97%)
		WD40 repeat	636..679	CDD:293791	37/42 (88%)
		WD40 repeat	685..707	CDD:293791	21/21 (100%)