Protein Alignment slmb and MET30

DIOPT Version :9

• Sequence 1: NP_001262802.1
• Gene: slmb / 42504
• FlyBaseID: FBgn0283468
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_012218.1
• Gene: MET30 / 854765
• SGDID: S000001308
• Length: 640
• Species: Saccharomyces cerevisiae
• Alignment Length: 503
• Identity: 142/503 - (28%)
• Similarity: 227/503 - (45%)
• Gaps: 128/503 - (25%)

  Fly    61 VEHLLSRMCHYQHGQINAYLKPMLQRDFITLLPIKGLDHIAENILSYLDAESLKSSELVCKEWLR 125
            ::.:||..|..|...|::.:..|::.|||::||    ..::..||||||.:||.::..||::|.:
Yeast   156 LDGILSTSCFPQLSYISSLVTHMIKIDFISILP----QELSLKILSYLDCQSLCNATRVCRKWQK 216

  Fly   126 VISEGMLWKKLIERKVRTDSLWRGLAERR----NW---MQYLFKPR--------------PGQTQ 169
            :..:..:|..:.|:.:          :|:    .|   :.::.:.|              ..||.
Yeast   217 LADDDRVWYHMCEQHI----------DRKCPNCGWGLPLLHMKRARIQQNSTGSSSNADIQTQTT 271

  Fly   170 RPHS-FHRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSK----GVYCLQYDDGKIVSGLRD 229
            ||.. .:||.|        .:|:|||.|       :||.:..|    ||..||::...:.:|..|
Yeast   272 RPWKVIYRERF--------KVESNWRKG-------HCRIQEFKGHMDGVLTLQFNYRLLFTGSYD 321

  Fly   230 NTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVL 294
            :||.|||....:.::.|.||:..|..|.:||:.:|:||.|.|:|||:..|||.::|...|.::||
Yeast   322 STIGIWDLFTGKLIRRLSGHSDGVKTLYFDDRKLITGSLDKTIRVWNYITGECISTYRGHSDSVL 386

  Fly   295 HLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYI--VSASGDRTIKV 357
            .:.....::|:.|.|:::.||.:.|.:..|||    ||...||.|....|..  .|.|.|.||::
Yeast   387 SVDSYQKVIVSGSADKTVKVWHVESRTCYTLR----GHTEWVNCVKLHPKSFSCFSCSDDTTIRM 447

  Fly   358 WS--TSSCEFVRTLNGH---KRGIACLQYRD--RLVVSGSS------------------------ 391
            |.  |:||  ::...||   .:.|..|..:|  .|....:|
Yeast   448 WDIRTNSC--LKVFRGHVGQVQKIIPLTIKDVENLATDNTSDGSSPQDDPTMTDGADESDTPSNE 510

  Fly   392 --------------------DNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIK 436
                                ||:|:|||::.|.|:|...||.|.|..|..|..||:||::||.||
Yeast   511 QETVLDENIPYPTHLLSCGLDNTIKLWDVKTGKCIRTQFGHVEGVWDIAADNFRIISGSHDGSIK 575

  Fly   437 VWDLVAALDPRAASNTLCLNTLVEHTGRVFRLQFDEFQIVSSSHDDTI 484
            ||||         .:..|::|.   .||  |||.:.....:.|..|.:
Yeast   576 VWDL---------QSGKCMHTF---NGR--RLQRETQHTQTQSLGDKV 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:288940	6/23 (26%)
		F-box-like	89..136	CDD:289689	15/46 (33%)
		WD40	<192..495	CDD:225201	107/350 (31%)
		WD40	210..488	CDD:238121	101/332 (30%)
		WD40 repeat	213..248	CDD:293791	11/34 (32%)
		WD40 repeat	254..288	CDD:293791	15/33 (45%)
		WD40 repeat	293..330	CDD:293791	11/36 (31%)
		WD40 repeat	337..370	CDD:293791	12/36 (33%)
		WD40 repeat	376..410	CDD:293791	14/79 (18%)
		WD40 repeat	416..459	CDD:293791	17/42 (40%)
		WD40 repeat	465..487	CDD:293791	5/20 (25%)
MET30	NP_012218.1	F-box-like	184..228	CDD:403981	15/47 (32%)
		WD40	295..590	CDD:238121	94/312 (30%)
		WD40 repeat	305..340	CDD:293791	11/34 (32%)
		WD40 repeat	346..380	CDD:293791	15/33 (45%)
		WD40 repeat	385..418	CDD:293791	9/32 (28%)
		WD40 repeat	425..460	CDD:293791	12/36 (33%)
		WD40 repeat	488..549	CDD:293791	9/60 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I1030
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.990