DRSC/TRiP Functional Genomics Resources

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Protein Alignment slmb and PAC1

DIOPT Version :10

Sequence 1:NP_001262802.1 Gene:slmb / 42504 FlyBaseID:FBgn0283468 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_014912.1 Gene:PAC1 / 854443 SGDID:S000005795 Length:494 Species:Saccharomyces cerevisiae


Alignment Length:451 Identity:99/451 - (21%)
Similarity:161/451 - (35%) Gaps:152/451 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 SYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGLAERRNWMQYL--FKPRPGQT 168
            |.:|.:.|    |:.|:|..::   .|.||:||.:..|::|...:.:....:..|  |||.....
Yeast    76 SMVDIDEL----LLPKKWNSIV---RLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNG 133

  Fly   169 QRPHSF------------------------------------HRELF-----------------P 180
            ...|:.                                    |.:|:                 .
Yeast   134 TSAHNVLKWIPRNLPSCLINVESSVTSVKLHPNLPIVFVATDHGKLYAFDLFNYTIPLASLQSHT 198

  Fly   181 KIMNDIDSIENNWRTGR----------------HMLRRIN--CRSENSKGVYCLQY--------- 218
            |.:..:|.:..|:....                |:.:.::  |:.:..:.:...::         
Yeast   199 KAITSMDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEECKFQQIRSLLGHEHIVSAVKIWQ 263

  Fly   219 --DDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRV--WDVNT 279
              :|..|.|..||.|:||||..:...:||...|:..|..:......|||||.|:|:|:  |....
Yeast   264 KNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWVRSIDVLGDYIISGSHDTTLRLTHWPSGN 328

  Fly   280 GEMVNT----------LIHHCEAVLHLRF---------NNGMM--VTCSKDRSIAVWDMTSPSEI 323
            |..|.|          .||..|....:||         |.||.  |:.|:||:|.:|::..|:  
Yeast   329 GLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTPSTDRYKNWGMQYCVSASRDRTIKIWEIPLPT-- 391

  Fly   324 TLRRVLVGHRAAV-NVVDFDEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACLQYRDRLVV 387
                 |:.|||.: |..|                    |:...|.||.||...:..:..|.:.:.
Yeast   392 -----LMAHRAPIPNPTD--------------------SNFRCVLTLKGHLSWVRDISIRGQYLF 431

  Fly   388 SGSSDNSIRLWDIECGACLRVLEG-HEELVRCIRFDT---------KRIVSGAYDGKIKVW 438
            |.:.|.|:|.||:..|.||.|.|. |...|.|:..|.         :.:|:|..|.|..|:
Yeast   432 SCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMMVTGGLDCKSNVF 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slmbNP_001262802.1 Beta-TrCP_D 47..85 CDD:463465
F-box_FBXW1B 85..135 CDD:438954 7/28 (25%)
WD40 210..488 CDD:238121 74/274 (27%)
WD40 repeat 213..248 CDD:293791 12/45 (27%)
WD40 repeat 254..288 CDD:293791 12/45 (27%)
WD40 repeat 293..330 CDD:293791 12/47 (26%)
WD40 repeat 337..370 CDD:293791 5/32 (16%)
WD40 repeat 376..410 CDD:293791 11/33 (33%)
WD40 repeat 416..459 CDD:293791 8/32 (25%)
WD40 repeat 465..487 CDD:293791
PAC1NP_014912.1 WD40 155..492 CDD:238121 80/363 (22%)
WD40 repeat 158..196 CDD:293791 2/37 (5%)
WD40 repeat 202..251 CDD:293791 4/48 (8%)
WD40 repeat 256..294 CDD:293791 12/37 (32%)
WD40 repeat 301..339 CDD:293791 12/37 (32%)
WD40 repeat 346..414 CDD:293791 24/94 (26%)
WD40 repeat 420..458 CDD:293791 12/37 (32%)
WD40 repeat 465..492 CDD:293791 5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

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