DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slmb and fbxw7

DIOPT Version :9

Sequence 1:	NP_001262802.1	Gene:	slmb / 42504	FlyBaseID:	FBgn0283468	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_009289569.3	Gene:	fbxw7 / 564991	ZFINID:	ZDB-GENE-090313-79	Length:	835	Species:	Danio rerio

Alignment Length:	579	Identity:	167/579 - (28%)
Similarity:	269/579 - (46%)	Gaps:	106/579 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQRDFITLL 92
            |.|::.:|....|..:...:.|..||...::..::.|:......|...:...::|..|||||:||
Zfish   347 PQRRRITSIQPPTGLQEWLRTFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLL 411

  Fly    93 PIKGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGL-AERRNW 156
            |    ..:|.::||:|:.:.|..:...|:.|..:..:.:|||:    |.:.:.:...| .:||..
Zfish   412 P----RELALHVLSFLEPKDLLQAAQTCRYWRILAEDNLLWKE----KCKEEGIDEPLHIKRRKV 468

  Fly   157 MQYLFKPRPGQTQRPHSF-----HRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCL 216
            :      :||.|..|...     ||            |:.|||.|.....::..:..:...:.||
Zfish   469 I------KPGFTHSPWKSAYIRQHR------------IDTNWRRGDLKSPKVVLKGHDDHVITCL 515

  Fly   217 QYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGE 281
            |:...:||||..|||:|:|.....:|::||:||||.|...|..|.:|||||:|.|::||:..|||
Zfish   516 QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGE 580

  Fly   282 MVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYI 346
            .::||..|...|..:..:...:|:.|:|.::.|||:.:...:   .||:||.|||..|.:|.:.:
Zfish   581 CIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 642

  Fly   347 VSASGDRTIKVW--STSSCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNSIRLWDIECGACLRVL 409
            ||.:.|..:|||  .|.:|  :.||.||...:..||:....|||||.|.|||:||:|.|.|:..|
Zfish   643 VSGAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 705

  Fly   410 EGHEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCLNTLV---EHTGRVFRLQFD 471
            .||:.|...:......:|||..|..:|:||:         ....||.||.   :|...|..|||:
Zfish   706 TGHQSLTSGMELKDNILVSGNADSTVKIWDI---------KTGQCLQTLQGPHKHQSAVTCLQFN 761

  Fly   472 EFQIVSSSHDDTILIWDFLNFTPNENKTGRTPSPALMEHXHFVQRQLRELHLQSSSEGEEDDDAD 536
            :..:::||.|.|:.:||.        :||           .|::..:.   |:|...
Zfish   762 KNFVITSSDDGTVKLWDL--------RTG-----------EFIRNLVT---LESGGS-------- 796

  Fly   537 EDDEDDFEEEDSRNDAGAFMGGYVRHRDAGGSGSVTGSGSDPESDD-----LDFDIDVE 590
                                ||.|....|..:..|...||...:::     ||||:|::
Zfish   797 --------------------GGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:288940	6/37 (16%)
		F-box-like	89..136	CDD:289689	14/46 (30%)
		WD40	<192..495	CDD:225201	111/307 (36%)
		WD40	210..488	CDD:238121	105/282 (37%)
		WD40 repeat	213..248	CDD:293791	15/34 (44%)
		WD40 repeat	254..288	CDD:293791	16/33 (48%)
		WD40 repeat	293..330	CDD:293791	8/36 (22%)
		WD40 repeat	337..370	CDD:293791	11/34 (32%)
		WD40 repeat	376..410	CDD:293791	16/33 (48%)
		WD40 repeat	416..459	CDD:293791	10/42 (24%)
		WD40 repeat	465..487	CDD:293791	8/21 (38%)
fbxw7	XP_009289569.3	F-box-like	408..452	CDD:315592	14/51 (27%)
		WD40	503..778	CDD:238121	105/288 (36%)
		WD40 repeat	512..547	CDD:293791	15/34 (44%)
		WD40 repeat	553..587	CDD:293791	16/33 (48%)
		WD40 repeat	592..626	CDD:293791	8/36 (22%)
		WD40 repeat	633..666	CDD:293791	11/34 (32%)
		WD40 repeat	672..706	CDD:293791	16/33 (48%)
		WD40 repeat	714..746	CDD:293791	10/40 (25%)
		WD40 repeat	755..777	CDD:293791	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44156
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.040