DRSC/TRiP Functional Genomics Resources

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Protein Alignment slmb and FBXW7

DIOPT Version :9

Sequence 1:NP_001262802.1 Gene:slmb / 42504 FlyBaseID:FBgn0283468 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001336727.1 Gene:FBXW7 / 55294 HGNCID:16712 Length:707 Species:Homo sapiens


Alignment Length:577 Identity:165/577 - (28%)
Similarity:266/577 - (46%) Gaps:107/577 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 RKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQRDFITLLPI 94
            |::.:|....|..:...:.|..||...::..::.|:......|...:...::|..|||||:||| 
Human   222 RRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLP- 285

  Fly    95 KGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGL-AERRNWMQ 158
               ..:|..:||:|:.:.|..:...|:.|..:..:.:||::    |.:.:.:...| .:||..: 
Human   286 ---KELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE----KCKEEGIDEPLHIKRRKVI- 342

  Fly   159 YLFKPRPGQTQRPHSF-----HRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCLQY 218
                 :||....|...     ||            |:.|||.|.....:: .:..:...:.|||:
Human   343 -----KPGFIHSPWKSAYIRQHR------------IDTNWRRGELKSPKV-LKGHDDHVITCLQF 389

  Fly   219 DDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGEMV 283
            ...:||||..|||:|:|.....:|::||:||||.|...|..|.:|||||:|.|::||:..|||.:
Human   390 CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECI 454

  Fly   284 NTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYIVS 348
            :||..|...|..:..:...:|:.|:|.::.|||:.:...:   .||:||.|||..|.:|.:.:||
Human   455 HTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRVVS 516

  Fly   349 ASGDRTIKVW--STSSCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNSIRLWDIECGACLRVLEG 411
            .:.|..:|||  .|.:|  :.||.||...:..||:....|||||.|.|||:||:|.|.|:..|.|
Human   517 GAYDFMVKVWDPETETC--LHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTG 579

  Fly   412 HEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCLNTLV---EHTGRVFRLQFDEF 473
            |:.|...:......:|||..|..:|:||:         ....||.||.   :|...|..|||::.
Human   580 HQSLTSGMELKDNILVSGNADSTVKIWDI---------KTGQCLQTLQGPNKHQSAVTCLQFNKN 635

  Fly   474 QIVSSSHDDTILIWDFLNFTPNENKTGRTPSPALMEHXHFVQRQLRELHLQSSSEGEEDDDADED 538
            .:::||.|.|:.:||.        |||           .|::..:.   |:|...          
Human   636 FVITSSDDGTVKLWDL--------KTG-----------EFIRNLVT---LESGGS---------- 668

  Fly   539 DEDDFEEEDSRNDAGAFMGGYVRHRDAGGSGSVTGSGSDPESDD-----LDFDIDVE 590
                              ||.|....|..:..|...||...:::     ||||:|::
Human   669 ------------------GGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slmbNP_001262802.1 Beta-TrCP_D 47..85 CDD:288940 6/37 (16%)
F-box-like 89..136 CDD:289689 13/46 (28%)
WD40 <192..495 CDD:225201 111/307 (36%)
WD40 210..488 CDD:238121 105/282 (37%)
WD40 repeat 213..248 CDD:293791 15/34 (44%)
WD40 repeat 254..288 CDD:293791 16/33 (48%)
WD40 repeat 293..330 CDD:293791 8/36 (22%)
WD40 repeat 337..370 CDD:293791 11/34 (32%)
WD40 repeat 376..410 CDD:293791 16/33 (48%)
WD40 repeat 416..459 CDD:293791 10/42 (24%)
WD40 repeat 465..487 CDD:293791 8/21 (38%)
FBXW7NP_001336727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..151
F-box-like 281..325 CDD:403981 13/51 (25%)
WD40 374..650 CDD:238121 105/290 (36%)
WD 1 378..418 14/39 (36%)
WD40 repeat 384..419 CDD:293791 15/34 (44%)
WD 2 420..456 18/35 (51%)
WD40 repeat 425..459 CDD:293791 16/33 (48%)
WD 3 459..498 9/41 (22%)
WD40 repeat 464..498 CDD:293791 8/36 (22%)
WD 4 500..536 14/37 (38%)
WD40 repeat 505..538 CDD:293791 11/34 (32%)
WD 5 539..578 18/38 (47%)
WD40 repeat 544..578 CDD:293791 16/33 (48%)
WD 6 580..618 12/46 (26%)
WD40 repeat 586..618 CDD:293791 10/40 (25%)
WD 7 622..659 15/55 (27%)
WD40 repeat 627..649 CDD:293791 8/21 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R947
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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