DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slmb and btrc

DIOPT Version :9

Sequence 1:	NP_001262802.1	Gene:	slmb / 42504	FlyBaseID:	FBgn0283468	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_012822030.1	Gene:	btrc / 549140	XenbaseID:	XB-GENE-486122	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	397/504 - (78%)
Similarity:	442/504 - (87%)	Gaps:	9/504 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 METDKIMDETN-SNAQAFTTTMLYDPVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSR 67
            |:|:..:.:|. :|.   |::|:....||  .|..|:.|:|||.:||.||||..||:|||||:||
Frog   105 MKTESCVVKTKLANG---TSSMIVPKQRK--LSANYEKEKELCVKYFEQWSECDQVEFVEHLISR 164

  Fly    68 MCHYQHGQINAYLKPMLQRDFITLLPIKGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGML 132
            |||||||.||.||||||||||||.||.:|||||||||||||||.||.|:|||||||.||.|:|||
Frog   165 MCHYQHGHINTYLKPMLQRDFITALPARGLDHIAENILSYLDARSLCSAELVCKEWYRVTSDGML 229

  Fly   133 WKKLIERKVRTDSLWRGLAERRNWMQYLFKPRP--GQTQRPHSFHRELFPKIMNDIDSIENNWRT 195
            |||||||.||||||||||||||.|.|||||.:|  |:|. |:||:|.|:|||:.||::||:|||.
Frog   230 WKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGKTP-PNSFYRALYPKIIQDIETIESNWRC 293

  Fly   196 GRHMLRRINCRSENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDD 260
            |||.|:||:||||.|||||||||||.|||||||||||||||:..|:|.:.||||||||||||||:
Frog   294 GRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRVLMGHTGSVLCLQYDE 358

  Fly   261 KVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITL 325
            :|||:|||||||||||||||||:||||||||||||||||||||||||||||||||||.|.::|||
Frog   359 RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASATDITL 423

  Fly   326 RRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACLQYRDRLVVSGS 390
            |||||||||||||||||:|||||||||||||||:||:||||||||||||||||||||||||||||
Frog   424 RRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGS 488

  Fly   391 SDNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCL 455
            |||:||||||||||||||||||||||||||||.|||||||||||||||||||||||||.:.||||
Frog   489 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCL 553

  Fly   456 NTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNFTPNENKTGRTPS 504
            .|||||:|||||||||||||||||||||||||||||......::.|:||
Frog   554 RTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAESTRSPS 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:288940	29/37 (78%)
		F-box-like	89..136	CDD:289689	37/46 (80%)
		WD40	<192..495	CDD:225201	269/302 (89%)
		WD40	210..488	CDD:238121	251/277 (91%)
		WD40 repeat	213..248	CDD:293791	26/34 (76%)
		WD40 repeat	254..288	CDD:293791	29/33 (88%)
		WD40 repeat	293..330	CDD:293791	32/36 (89%)
		WD40 repeat	337..370	CDD:293791	29/32 (91%)
		WD40 repeat	376..410	CDD:293791	32/33 (97%)
		WD40 repeat	416..459	CDD:293791	37/42 (88%)
		WD40 repeat	465..487	CDD:293791	21/21 (100%)
btrc	XP_012822030.1	Beta-TrCP_D	144..182	CDD:288940	29/37 (78%)
		F-box-like	186..233	CDD:289689	37/46 (80%)
		WD40	<295..591	CDD:225201	265/295 (90%)
		WD40	308..586	CDD:238121	251/277 (91%)
		WD40 repeat	311..346	CDD:293791	26/34 (76%)
		WD40 repeat	352..386	CDD:293791	29/33 (88%)
		WD40 repeat	391..428	CDD:293791	32/36 (89%)
		WD40 repeat	435..468	CDD:293791	29/32 (91%)
		WD40 repeat	474..508	CDD:293791	32/33 (97%)
		WD40 repeat	514..557	CDD:293791	37/42 (88%)
		WD40 repeat	563..585	CDD:293791	21/21 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6455
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39330
Inparanoid	1	1.050	807	1.000	Inparanoid score	I480
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150270at33208
OrthoFinder	1	1.000	-	-		FOG0002886
OrthoInspector	1	1.000	-	-		oto103901
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	1	1.000	-	-		X2712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090