Protein Alignment slmb and WDY

DIOPT Version :10

• Sequence 1: NP_001262802.1
• Gene: slmb / 42504
• FlyBaseID: FBgn0283468
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001303588.1
• Gene: WDY / 26067056
• FlyBaseID: FBgn0267449
• Length: 1069
• Species: Drosophila melanogaster
• Alignment Length: 670
• Identity: 125/670 - (18%)
• Similarity: 226/670 - (33%)
• Gaps: 253/670 - (37%)

  Fly    52 WSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQRDFITLLPIKG-------------------- 96
            |:|     ||.:|:   ..:|...      |..|::.: :|||.|
  Fly    97 WNE-----FVSYLI---FGFQEED------PSSQKESL-ILPISGPPMVRKSEHRSAICCLALLK 146

  Fly    97 -------LDHIAENI-LSYLDAESLKSSELVCKEWLRVISEGML--WKKLIE--RKVRTDSL--- 146
                   :|.:.|.| .|:...:|.::|.:    |:....|||:  |...:|  |...::|:
  Fly   147 AKSDQVPIDEVTETINFSFGGEDSPEASGM----WVTASHEGMMRFWTSHMEPIRTASSESICMS 207

  Fly   147 -----------------WRGLAERRNWMQYL---FKPRPG------------QTQRPHSF----- 174
                             :.|.....::..:|   |:.:||            :.:.|..|
  Fly   208 YAFFNNGKVHSKLILGDYAGNVRVLSYSPHLRGPFQAKPGAALIEVVWSDILRGKIPQFFPKEYI 272

  Fly   175 --HREL-----FPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCLQYDDGK---------- 222
              |.|:     |...||.:.:......|.::   |..|     .|:..:.||:..
  Fly   273 NLHNEMVSCVYFSLHMNALFASAEYRNTKKY---RGRC-----PGMIMVTYDERSNFRIPLGVST 329

  Fly   223 ---------IVSGLRDNTIKIWD---RTDLQCVKTLMGHTGSVLC--LQYDDKVIISGSSDSTVR 273
                     :|:|..|..::|||   .|:...:  |.||.|.::.  :|.::..:.|......::
  Fly   330 FFVAESHNIVVTGGPDTFVRIWDVYIPTEPSAI--LTGHNGGIVLVFVQPEENKVYSVDYQKIIK 392

  Fly   274 VWDVNTGEMVNT------LIHHCEAVL------HLR----------------------------- 297
            |||::...::.|      ||||.|..|      |||
  Fly   393 VWDLHEHTLLQTYGDLVRLIHHSETDLTYYYHSHLRELVVAGRKLISIKCCPRVRVDLTDGNTHA 457

  Fly   298 -----------FNNGMMVTCSKDRSIAVWD-MTSPSEITLR----RVLVGHRAAVNVVD--FD-- 342
                       |.|  :|:|..|..|.||| .|...:|.::    :::.|....:.:..  ||
  Fly   458 APVSVVLYNRLFRN--IVSCGLDSYIIVWDPWTGRRKIIMKSCHTKMIYGEIIDIEITAACFDPL 520

  Fly   343 EKYIVSASGDRTIKVWSTSSCEFVRTLN--GHKRGIACLQYRDRLVVSGSSDNSIRLWDI---EC 402
            |:::::.:.|.::|:|:.::...||.::  ..:...|.:...||::..|.........|:   |.
  Fly   521 EQFLLTGARDGSLKIWNYNNAVVVRNMSIMPDQEVTAVIWVVDRILAMGWDRQVTEFNDVVGREY 585

  Fly   403 GACLRVLEGHEELVRCIRFDTK---RIVSGAYDGKIKVWDL--------VAALDP---------- 446
            |...:..:.|.:.:.|.  |.|   .:|:..|.|:|..|.|        .:.:||
  Fly   586 GDPKKWPKFHTDDITCA--DVKLGEGVVTATYSGEIIFWKLETGQPYRRYSVMDPTRFIELKLTA 648

  Fly   447 ----------RAASNTLCLNTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNFTPNENKTGR 501
                      |.||...........|||..|              .|:|      ..|.:|:...
  Fly   649 EEEKFIRQSKRLASRLTHSGNHSLQTGRAGR--------------STVL------NRPEDNRDYG 693

  Fly   502 TPSPALMEHXHFVQRQLREL 521
            |..|..::...|:|.:.:.|
  Fly   694 TDIPISVQAVLFLQTRPQTL 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:463465	7/32 (22%)
		F-box_FBXW1B	85..135	CDD:438954	16/79 (20%)
		WD40	210..488	CDD:238121	77/398 (19%)
		WD40 repeat	213..248	CDD:293791	10/56 (18%)
		WD40 repeat	254..288	CDD:293791	7/41 (17%)
		WD40 repeat	293..330	CDD:293791	15/87 (17%)
		WD40 repeat	337..370	CDD:293791	8/36 (22%)
		WD40 repeat	376..410	CDD:293791	7/36 (19%)
		WD40 repeat	416..459	CDD:293791	14/73 (19%)
		WD40 repeat	465..487	CDD:293791	3/21 (14%)
WDY	NP_001303588.1	WD40 repeat	279..316	CDD:293791	7/44 (16%)
		WD40	337..623	CDD:475233	61/291 (21%)
		WD40 repeat	370..406	CDD:293791	6/35 (17%)
		WD40 repeat	460..497	CDD:293791	11/38 (29%)
		WD40	512..869	CDD:475233	43/224 (19%)
		WD40 repeat	512..538	CDD:293791	6/25 (24%)
		WD40 repeat	555..593	CDD:293791	7/37 (19%)
		WD40 repeat	600..622	CDD:293791	7/23 (30%)