Protein Alignment slmb and sel-10

DIOPT Version :10

• Sequence 1: NP_001262802.1
• Gene: slmb / 42504
• FlyBaseID: FBgn0283468
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_506421.1
• Gene: sel-10 / 179878
• WormBaseID: WBGene00004767
• Length: 587
• Species: Caenorhabditis elegans
• Alignment Length: 507
• Identity: 149/507 - (29%)
• Similarity: 222/507 - (43%)
• Gaps: 89/507 - (17%)

  Fly    28 PVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLL--SRMCHYQHGQINAYLKPMLQRDFIT 90
            |.|..|.:|..    |.....|...|.:.|:|....||  |.|.:.:  |:.|.::|..||||::
 Worm    67 PSRNNDLNPRV----EHLIALFKDLSSAEQMDAFTRLLQESNMTNIR--QLRAIIEPHFQRDFLS 125

  Fly    91 LLPIKGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGLAERRN 155
            .||::....|..|:..|   :.||.:: |.|.| ::|||             .|.:|:.|....
 Worm   126 CLPVELGMKILHNLTGY---DLLKVAQ-VSKNW-KLISE-------------IDKIWKSLGVEE- 171

  Fly   156 WMQYLFKPRPGQTQR-----------------PH------SFHRELFPKIMNDI----------- 186
                 ||..|..|.|                 .|      :.||.|..:...||
 Worm   172 -----FKHHPDPTDRVTGAWQGTAIAAGVTIPDHIQPCDLNVHRFLKLQKFGDIFERAADKSRYL 231

  Fly   187 --DSIENNWRTGRHMLRRINCRSENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGH 249
              |.||.||.....|...: .|......:.|:|..|..:|:|..|||:|:|.....:.:.||:||
 Worm   232 RADKIEKNWNANPIMGSAV-LRGHEDHVITCMQIHDDVLVTGSDDNTLKVWCIDKGEVMYTLVGH 295

  Fly   250 TGSVLCLQYDD--KVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSI 312
            ||.|...|...  :.|:|||:|.||:||....|.:::||..|...|..:.....::||.|:|.::
 Worm   296 TGGVWTSQISQCGRYIVSGSTDRTVKVWSTVDGSLLHTLQGHTSTVRCMAMAGSILVTGSRDTTL 360

  Fly   313 AVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIA 377
            .|||:.|...:.   .|.||.|||..|.||...:||...|.|:|:|:..:...:|||.||...:.
 Worm   361 RVWDVESGRHLA---TLHGHHAAVRCVQFDGTTVVSGGYDFTVKIWNAHTGRCIRTLTGHNNRVY 422

  Fly   378 CLQYRDR--LVVSGSSDNSIRLWDI---ECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKV 437
            .|.:...  :|.|||.|.|||:||.   |...|:.:|:||..|...::.....:||...|..::|
 Worm   423 SLLFESERSIVCSGSLDTSIRVWDFTRPEGQECVALLQGHTSLTSGMQLRGNILVSCNADSHVRV 487

  Fly   438 WDLVAALDPRAASNTLCLNTLVEHTGRVFRLQ-FDEFQIVSSSHDDTILIWD 488
            ||:         ....|::.|..|...:..|| |....:.:||.|.|:.:||
 Worm   488 WDI---------HEGTCVHMLSGHRSAITSLQWFGRNMVATSSDDGTVKLWD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:463465	11/39 (28%)
		F-box_FBXW1B	85..135	CDD:438954	17/49 (35%)
		WD40	210..488	CDD:238121	93/285 (33%)
		WD40 repeat	213..248	CDD:293791	12/34 (35%)
		WD40 repeat	254..288	CDD:293791	13/35 (37%)
		WD40 repeat	293..330	CDD:293791	9/36 (25%)
		WD40 repeat	337..370	CDD:293791	11/32 (34%)
		WD40 repeat	376..410	CDD:293791	13/38 (34%)
		WD40 repeat	416..459	CDD:293791	7/42 (17%)
		WD40 repeat	465..487	CDD:293791	7/22 (32%)
sel-10	NP_506421.1	F-box_SF	107..165	CDD:459239	21/77 (27%)
		WD40	248..530	CDD:238121	94/294 (32%)
		WD40 repeat	259..294	CDD:293791	12/34 (35%)
		WD40 repeat	300..336	CDD:293791	13/35 (37%)
		WD40 repeat	341..375	CDD:293791	9/36 (25%)
		WD40 repeat	382..415	CDD:293791	11/32 (34%)
		WD40 repeat	421..460	CDD:293791	13/38 (34%)
		WD40 repeat	468..500	CDD:293791	7/40 (18%)
		WD40	495..>572	CDD:475233	12/36 (33%)
		WD40 repeat	506..529	CDD:293791	7/22 (32%)