Protein Alignment slmb and ago

DIOPT Version :10

• Sequence 1: NP_001262802.1
• Gene: slmb / 42504
• FlyBaseID: FBgn0283468
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_061504456.1
• Gene: ago / 1276064
• VectorBaseID: AGAMI1_013999
• Length: 1663
• Species: Anopheles gambiae
• Alignment Length: 640
• Identity: 184/640 - (28%)
• Similarity: 265/640 - (41%)
• Gaps: 169/640 - (26%)

  Fly    13 TNSNAQAFTTTMLYDPV--------------------------RK--------KDSSPTYQTERE 43
            |.::|.|.|||.|...|                          ||        ||:.|.     |
Mosquito  1122 TTTSASAVTTTPLSSGVVATTPRSSLRSPMNIATTPTSSTLGERKTPRTIIPTKDNPPP-----E 1181

  Fly    44 LC--FQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLK---PMLQRDFITLLPIKGLDHIAEN 103
            ||  ...|.:|:...::..|:.|:.   |.:..|:...:|   |..|||||:|||    ..:|..
Mosquito  1182 LCEWLMQFQRWTHVERLLAVDRLIE---HCEPTQVRHMMKVIEPQFQRDFISLLP----KELALQ 1239

  Fly   104 ILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIER-----KVRTDSLWRGLAERRNWMQYLFKP 163
            :||||:.:.|..:...|:.|..:..:.:|||:..:.     :..||...||   |...|..:..|
Mosquito  1240 VLSYLEPKDLLRAAQTCRSWRFLADDNLLWKEKCKESGIGIEPSTDRPKRG---RTGNMPPISSP 1301

  Fly   164 RPGQTQRPHSFHRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCLQYDDGKIVSGLR 228
            ......|.|               .||.|||:......:: .:..:...:.|||:...:||||..
Mosquito  1302 WKAAYMRQH---------------IIEMNWRSRPIRTAKV-LKGHDDHVITCLQFCGNRIVSGSD 1350

  Fly   229 DNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAV 293
            |||:|:|.....:|::||.||||.|...|....:|||||:|.|:|||..:||:.::.|..|...|
Mosquito  1351 DNTLKVWSAITGKCLRTLTGHTGGVWSSQMSGNIIISGSTDRTLRVWKADTGQCMHILHGHTSTV 1415

  Fly   294 LHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVW 358
            ..:..:...:|:.|:|.::.|||:...   |...:||||.|||..|.:|.|.|||.:.|..:|||
Mosquito  1416 RCMHLHGNKVVSGSRDATLRVWDVNLG---TCLHMLVGHLAAVRCVQYDGKLIVSGAYDYMVKVW 1477

  Fly   359 STSSCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNSIRLWDIECGACLRVLEGHEELVRCIRFDT 423
            :....|.:.||.||...:..||:....|||||.|.|||:||.|.|:|...|.||:.|...:....
Mosquito  1478 NPERQECLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDAETGSCKHALMGHQSLTSGMELRQ 1542

  Fly   424 KRIVSGAYDGKIKVWDLVAALDPRAASNTLCLNTLV---EHTGRVFRLQFDEFQIVSSSHDDTIL 485
            ..:|||..|..:||||::..         .||.||.   :|...|..|||:...:::||.|.|:.
Mosquito  1543 NILVSGNADSTVKVWDIITG---------QCLQTLSGPNKHQSAVTCLQFNSRFVITSSDDGTVK 1598

  Fly   486 IWDFLNFTPNENKTGRTPSPALMEHXHFVQRQLRELHLQSSSEGEEDDDADEDDEDDFEEEDSRN 550
            :||.        |||..               :|.|.|..|
Mosquito  1599 LWDV--------KTGEF---------------IRNLVLLES------------------------ 1616

  Fly   551 DAGAFMGGYVRHRDAGGSGSV--------------TGSGSDPESDD---LDFDID 588
                           ||||.|              .||.:..|...   ||||::
Mosquito  1617 ---------------GGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVE 1656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slmb	NP_001262802.1	Beta-TrCP_D	47..85	CDD:463465	8/40 (20%)
		F-box_FBXW1B	85..135	CDD:438954	18/49 (37%)
		WD40	210..488	CDD:238121	106/280 (38%)
		WD40 repeat	213..248	CDD:293791	15/34 (44%)
		WD40 repeat	254..288	CDD:293791	14/33 (42%)
		WD40 repeat	293..330	CDD:293791	8/36 (22%)
		WD40 repeat	337..370	CDD:293791	12/32 (38%)
		WD40 repeat	376..410	CDD:293791	16/33 (48%)
		WD40 repeat	416..459	CDD:293791	11/42 (26%)
		WD40 repeat	465..487	CDD:293791	8/21 (38%)
ago	XP_061504456.1	None