DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppan and SSF2

DIOPT Version :9

Sequence 1:	NP_476979.1	Gene:	ppan / 42502	FlyBaseID:	FBgn0010770	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_010598.3	Gene:	SSF2 / 851907	SGDID:	S000002720	Length:	453	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	138/453 - (30%)
Similarity:	229/453 - (50%)	Gaps:	89/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRG---LACPYITDLTLDFRRIMEPFTASNLREKR 65
            ||:.|.:.        .|.:..:.|.|.||..|   ||...:..|..|||:||:|.||..|:|::
Yeast     7 KKRTHAQI--------TPEQERDIPKSMVIRVGQTSLANHSLNQLVKDFRQIMQPHTAVKLKERK 63

  Fly    66 MNRIKDFVSLSSFFHVSHMGIFNKA--STQLSFKVVRLPRGPSLTFKVHQFTLARDVIS-LSKKQ 127
            .|::||||.:.....|:|:.:|.::  :..:|.|:.|.|:||::||:|..::|.||:.. |.:.:
Yeast    64 SNKLKDFVVMCGPLGVTHLFMFTQSEKTGNVSLKIARTPQGPTVTFQVLDYSLGRDIKKFLKRPK 128

  Fly   128 MIDNDHFKHAPLVIMNNFS---------GDGKHLKLMATTFQNMFPSINLATVNIGTIRRCVLFS 183
            .::||...:.||:::|.||         .|....|::.:.|||:||.:|.|..::.:|:|..:.:
Yeast   129 SLNNDDVLNPPLLVLNGFSTSKRSDEDDQDVNVEKVIVSMFQNIFPPLNPARTSLNSIKRIFMIN 193

  Fly   184 YNPDTKLVEMRHYSVQVVPVGLKRAVQKIVKG------TVPNLGKCNEVVDFVTK---DGYASES 239
            .:.:|..:.||||.:.:..|.:.|.::::.|.      |||||.:..::...:..   ..|.|||
Yeast   194 KDRETGEISMRHYFIDIREVEISRNLKRLYKAKNNLSKTVPNLHRKEDISSLILDHDLGAYTSES 258

  Fly   240 EAEDDEQSHVVLAQTLKSKGN----------------------------LED-----------KK 265
            |.|||....||..|.:|:|.:                            :|:           :|
Yeast   259 EIEDDAIVRVVDNQDVKAKHSQTSLSQKTPVKMTDNEEREKGIEEEDVEMEEPKPSENSQPTPRK 323

  Fly   266 SSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQKEQRKKEQAEN 330
            .:|||.|:|||||::|:|||:|:.:|:||:|:.|.|:.:|.:.|.|....|.:.||||:|||.||
Yeast   324 KAIKLTELGPRLTLKLVKIEDGICSGKVLHHEFVQKSSEEIKALEKRHAAKMRLKEQRRKEQEEN 388

  Fly   331 RARNLKLKKD---------EKWAAKRAAEGR-------TDSDPEDDAEYYKEEVGEEPDEELF 377
            .|:. |..||         .|..|:...||:       .|.....:.|:| .:|.|:.|.:||
Yeast   389 IAKK-KAVKDAKKQRKLERRKARAEEQGEGQGKDGAMSDDGSSSSEDEHY-SDVPEDLDSDLF 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	62/195 (32%)
ppan	NP_476979.1	Brix	<215..295	CDD:294606	36/127 (28%)
SSF2	NP_010598.3	Brix	26..220	CDD:214879	62/193 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341478
Domainoid	1	1.000	137	1.000	Domainoid score	I1065
eggNOG	1	0.900	-	-		E1_KOG2963
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5690
Inparanoid	1	1.050	197	1.000	Inparanoid score	I873
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53510
OrthoFinder	1	1.000	-	-		FOG0004323
OrthoInspector	1	1.000	-	-		otm46665
orthoMCL	1	0.900	-	-		OOG6_101976
Panther	1	1.100	-	-	LDO	PTHR12661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1766
SonicParanoid	1	1.000	-	-		X3054
TreeFam	1	0.960	-	-
	15	14.790