DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppan and PPAN-P2RY11

DIOPT Version :9

Sequence 1:	NP_476979.1	Gene:	ppan / 42502	FlyBaseID:	FBgn0010770	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001035754.1	Gene:	PPAN-P2RY11 / 692312	HGNCID:	33526	Length:	794	Species:	Homo sapiens

Alignment Length:	436	Identity:	169/436 - (38%)
Similarity:	260/436 - (59%)	Gaps:	33/436 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG--GKKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRGLACPYITDLTLDFRRIMEPFTASNLRE 63
            ||  |:.: |.|...|..:..........|||||..||.....|..|:||.||:|||.|||.|:.
Human     1 MGQSGRSR-HQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQV 64

  Fly    64 KRMNRIKDFVSLSSFFHVSHMGIFNKASTQLSFKVVRLPRGPSLTFKVHQFTLARDVISLSKKQM 128
            ::.|.:||.|:::....|:|..|.:|..|.:.||::|||.||:|||:|.:::|.|||:|..::..
Human    65 RKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHR 129

  Fly   129 IDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDTKLVEM 193
            :....|.|.||:::|:|...|.|:|||||.|||:|||||:..||:.||:||:|..||||::.::.
Human   130 MHEQQFAHPPLLVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDF 194

  Fly   194 RHYSVQVVPVGLKRAVQKIVKGTVPNLGKCNEVVDFVTKDGYASESEAEDDEQSHVV-LAQTLKS 257
            ||||::|||||..|.::|:::...||:.:..::.:.:......||||||.|...::. |.|.:..
Human   195 RHYSIKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAG 259

  Fly   258 KGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQKEQ 322
            :||:..::|:::|.|||||:|:||||::||:..|:|::|..|.|||:|.:.:.:..|||.:.|.|
Human   260 RGNMRAQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQ 324

  Fly   323 RKKEQAEN-----------RARNLK-LKKDEKWAAKRAAEG---RT---------DSDPEDDAEY 363
            |:.:||:|           |.::|: :||.....:...|.|   ||         |...:||.||
Human   325 RQAQQAQNVQRKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEY 389

  Fly   364 YKEEVGEEPDEELFKMEAKSSRKRPSLGGGMKYKNKRAKLDTKDKN 409
            :.:.|||.|.|:||. |||..|...|.|    .|.||.::|...|:
Human   390 FCQAVGEAPSEDLFP-EAKQKRLAKSPG----RKRKRWEMDRGAKS 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	84/180 (47%)
ppan	NP_476979.1	Brix	<215..295	CDD:294606	29/80 (36%)
PPAN-P2RY11	NP_001035754.1	Brix	36..285	CDD:282306	106/248 (43%)
		Brix	<270..341	CDD:294606	30/70 (43%)
		7tm_1	466..741	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141372
Domainoid	1	1.000	227	1.000	Domainoid score	I2512
eggNOG	1	0.900	-	-		E1_KOG2963
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2729
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53510
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004323
OrthoInspector	1	1.000	-	-		oto89153
orthoMCL	1	0.900	-	-		OOG6_101976
Panther	1	1.100	-	-	LDO	PTHR12661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1766
SonicParanoid	1	1.000	-	-		X3054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790