Protein Alignment ppan and PPAN

DIOPT Version :10

• Sequence 1: NP_476979.1
• Gene: ppan / 42502
• FlyBaseID: FBgn0010770
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_064615.3
• Gene: PPAN / 56342
• HGNCID: 9227
• Length: 473
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 172/453 - (37%)
• Similarity: 265/453 - (58%)
• Gaps: 46/453 - (10%)

  Fly     1 MG--GKKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRGLACPYITDLTLDFRRIMEPFTASNLRE 63
            ||  |:.: |.|...|..:..........|||||..||.....|..|:||.||:|||.|||.|:.
Human     1 MGQSGRSR-HQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQV 64

  Fly    64 KRMNRIKDFVSLSSFFHVSHMGIFNKASTQLSFKVVRLPRGPSLTFKVHQFTLARDVISLSKKQM 128
            ::.|.:||.|:::....|:|..|.:|..|.:.||::|||.||:|||:|.:::|.|||:|..::..
Human    65 RKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHR 129

  Fly   129 IDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDTKLVEM 193
            :....|.|.||:::|:|...|.|:|||||.|||:|||||:..||:.||:||:|..||||::.::.
Human   130 MHEQQFAHPPLLVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDF 194

  Fly   194 RHYSVQVVPVGLKRAVQKIVKGTVPNLGKCNEVVDFVTKDGYASESEAEDDEQSHVV-LAQTLKS 257
            ||||::|||||..|.::|:::...||:.:..::.:.:......||||||.|...::. |.|.:..
Human   195 RHYSIKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAG 259

  Fly   258 KGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQKEQ 322
            :||:..::|:::|.|||||:|:||||::||:..|:|::|..|.|||:|.:.:.:..|||.:.|.|
Human   260 RGNMRAQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQ 324

  Fly   323 RKKEQAEN-----------RARNLK-LKKDEKWAAKRAAEG---RT---------DSDPEDDAEY 363
            |:.:||:|           |.::|: :||.....:...|.|   ||         |...:||.||
Human   325 RQAQQAQNVQRKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEY 389

  Fly   364 YKEEVGEEPDEELFKMEAKSSRKRPSLGGGMKYKNKRAKLD-------------TKDKNDKSE 413
            :.:.|||.|.|:||. |||..|...|.|    .|.||.::|             ||||:..::
Human   390 FCQAVGEAPSEDLFP-EAKQKRLAKSPG----RKRKRWEMDRGRGRLCDQKFPKTKDKSQGAQ 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	84/180 (47%)
		Brix	<215..295	CDD:469999	29/80 (36%)
PPAN	NP_064615.3	Brix	32..201	CDD:214879	78/168 (46%)
		Brix	<270..341	CDD:469999	30/70 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..473		39/130 (30%)