DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppan and PPAN

DIOPT Version :9

Sequence 1:	NP_476979.1	Gene:	ppan / 42502	FlyBaseID:	FBgn0010770	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_064615.3	Gene:	PPAN / 56342	HGNCID:	9227	Length:	473	Species:	Homo sapiens

Alignment Length:	453	Identity:	172/453 - (37%)
Similarity:	265/453 - (58%)	Gaps:	46/453 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG--GKKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRGLACPYITDLTLDFRRIMEPFTASNLRE 63
            ||  |:.: |.|...|..:..........|||||..||.....|..|:||.||:|||.|||.|:.
Human     1 MGQSGRSR-HQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQV 64

  Fly    64 KRMNRIKDFVSLSSFFHVSHMGIFNKASTQLSFKVVRLPRGPSLTFKVHQFTLARDVISLSKKQM 128
            ::.|.:||.|:::....|:|..|.:|..|.:.||::|||.||:|||:|.:::|.|||:|..::..
Human    65 RKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHR 129

  Fly   129 IDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDTKLVEM 193
            :....|.|.||:::|:|...|.|:|||||.|||:|||||:..||:.||:||:|..||||::.::.
Human   130 MHEQQFAHPPLLVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDF 194

  Fly   194 RHYSVQVVPVGLKRAVQKIVKGTVPNLGKCNEVVDFVTKDGYASESEAEDDEQSHVV-LAQTLKS 257
            ||||::|||||..|.::|:::...||:.:..::.:.:......||||||.|...::. |.|.:..
Human   195 RHYSIKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAG 259

  Fly   258 KGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQKEQ 322
            :||:..::|:::|.|||||:|:||||::||:..|:|::|..|.|||:|.:.:.:..|||.:.|.|
Human   260 RGNMRAQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQ 324

  Fly   323 RKKEQAEN-----------RARNLK-LKKDEKWAAKRAAEG---RT---------DSDPEDDAEY 363
            |:.:||:|           |.::|: :||.....:...|.|   ||         |...:||.||
Human   325 RQAQQAQNVQRKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEY 389

  Fly   364 YKEEVGEEPDEELFKMEAKSSRKRPSLGGGMKYKNKRAKLD-------------TKDKNDKSE 413
            :.:.|||.|.|:||. |||..|...|.|    .|.||.::|             ||||:..::
Human   390 FCQAVGEAPSEDLFP-EAKQKRLAKSPG----RKRKRWEMDRGRGRLCDQKFPKTKDKSQGAQ 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	84/180 (47%)
ppan	NP_476979.1	Brix	<215..295	CDD:294606	29/80 (36%)
PPAN	NP_064615.3	Brix	32..201	CDD:214879	78/168 (46%)
		Brix	<270..341	CDD:321259	30/70 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..473		39/130 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141371
Domainoid	1	1.000	227	1.000	Domainoid score	I2512
eggNOG	1	0.900	-	-		E1_KOG2963
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5690
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2729
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53510
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004323
OrthoInspector	1	1.000	-	-		oto89153
orthoMCL	1	0.900	-	-		OOG6_101976
Panther	1	1.100	-	-	LDO	PTHR12661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1766
SonicParanoid	1	1.000	-	-		X3054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830