DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppan and Ppan

DIOPT Version :9

Sequence 1:	NP_476979.1	Gene:	ppan / 42502	FlyBaseID:	FBgn0010770	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_663585.2	Gene:	Ppan / 235036	MGIID:	2178445	Length:	470	Species:	Mus musculus

Alignment Length:	483	Identity:	180/483 - (37%)
Similarity:	274/483 - (56%)	Gaps:	50/483 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG--GKKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRGLACPYITDLTLDFRRIMEPFTASNLRE 63
            ||  |:.: |.|...|..:..........|||||..||.|...:..|:||.||:|||.||:.|:.
Mouse     1 MGQSGRSR-HQKRNRAQAQLRNLESYAAQPHSFVFTRGRAGRNVRQLSLDVRRVMEPLTATRLQV 64

  Fly    64 KRMNRIKDFVSLSSFFHVSHMGIFNKASTQLSFKVVRLPRGPSLTFKVHQFTLARDVISLSKKQM 128
            ::.|.:||.|:::....|:|..|..|....:..|::|||.||:|||::.::||.|||:|..::..
Mouse    65 RKKNSLKDCVAVAGPLGVTHFLILTKTDNSVYLKLMRLPGGPTLTFQISKYTLIRDVVSSLRRHR 129

  Fly   129 IDNDHFKHAPLVIMNNFSGDGKHLKLMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDTKLVEM 193
            :....|.|.||:::|:|...|.|:|||||.|||:|||||:.|||:.||:||:|.:||||::.::.
Mouse   130 MHEQQFNHPPLLVLNSFGPQGMHIKLMATMFQNLFPSINVHTVNLNTIKRCLLINYNPDSQELDF 194

  Fly   194 RHYSVQVVPVGLKRAVQKIVKGTVPNLGKCNEVVDFVTKDGYASESEAE-DDEQSHVVLAQTLKS 257
            |||||:|||||..|.::|:::...||:.:..::.:.:......|:||.| |.|.:...|.|.:..
Mouse   195 RHYSVKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGVGLSDSEVEPDGEHNTTELPQAVAG 259

  Fly   258 KGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQKEQ 322
            :||::.::|:::|.|||||:|:|||||:||:..|.||:|..|.|||:|.:.:....|:|.:.|.|
Mouse   260 RGNMQAQQSAVRLTEIGPRMTLQLIKIQEGVGNGNVLFHSFVHKTEEELQAILAAKEEKLRLKAQ 324

  Fly   323 RKKEQAENRARNLKL----KKDEKWAAKRA---AEGRTDS----------------DPEDDAEYY 364
            |:.:||||..|..:|    ||......|||   |:|.:|:                |.||||||:
Mouse   325 RQNQQAENLQRKQELREAHKKKSLAGIKRARARADGDSDAEDPGAPPEAVGAGQPEDEEDDAEYF 389

  Fly   365 KEEVGEEPDEELFKMEAKSSRKRPSLGGGMKYKNKRAKLDTKDKNDKSERTDKYDRKD------- 422
            ::.|||||||:||...||..|:...||              |.:..|.:|.....|..
Mouse   390 RQAVGEEPDEDLFPTAAKRRRQGGPLG--------------KKQRGKEQRPGNKGRGQGGNWQAL 440

  Fly   423 KFDRKDKKDKFDPKNRRAKFD--PKNKR 448
            |...:.::.|..|:.|....|  |.::|
Mouse   441 KLQGRSQRGKAKPRPRATHQDSRPASRR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	83/180 (46%)
ppan	NP_476979.1	Brix	<215..295	CDD:294606	29/80 (36%)
Ppan	NP_663585.2	Brix	35..285	CDD:282306	104/249 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..264		9/23 (39%)
		Brix	<270..341	CDD:294606	34/70 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..470		48/160 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831309
Domainoid	1	1.000	223	1.000	Domainoid score	I2567
eggNOG	1	0.900	-	-		E1_KOG2963
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5690
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53510
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004323
OrthoInspector	1	1.000	-	-		oto92718
orthoMCL	1	0.900	-	-		OOG6_101976
Panther	1	1.100	-	-	LDO	PTHR12661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1766
SonicParanoid	1	1.000	-	-		X3054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790