DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppan and lpd-6

DIOPT Version :9

Sequence 1:	NP_476979.1	Gene:	ppan / 42502	FlyBaseID:	FBgn0010770	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_491108.2	Gene:	lpd-6 / 171886	WormBaseID:	WBGene00003062	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	148/414 - (35%)
Similarity:	241/414 - (58%)	Gaps:	16/414 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKVHPKTRTAAFKASEPSEIVEAPHSFVIHRGLACPYITDLTLDFRRIMEPFTASNLREKRMNR 68
            ::|...|.:...|..::..|:...||..|||||....|:..|..|.|.::||.||.||:..:.|.
Worm    32 QEKFVKKLQKQKFLENKEIELARQPHCLVIHRGDVGKYVKGLESDLRNLVEPNTAKNLKILKRNN 96

  Fly    69 IKDFVSLSSFFHVSHMGIFNKASTQLSFKVVRLPRGPSLTFKVHQFTLARDVISLSKKQMIDNDH 133
            ||||:...:...|::|.:...:...|..:::|..:||:|:|||.|::|||.|::..|:.:..:..
Worm    97 IKDFIVNGAVLGVTNMMVLTSSDASLQLRMMRFSQGPTLSFKVKQYSLARHVVNCQKRPVATDKL 161

  Fly   134 FKHAPLVIMNNFSGDG--KHLKLMATTFQNMFPSINLATVNIGTIRRCVLFSYNPDTKLVEMRHY 196
            ||.:|||:||.| |||  |||.|:.|..||||||||:.|:.:|.::||::.||:.:|..::|||:
Worm   162 FKSSPLVVMNGF-GDGTQKHLSLVQTFIQNMFPSINVDTIQLGNLKRCLIVSYDEETDEIQMRHF 225

  Fly   197 SVQVVPVGLKRAVQKIVKG------TVPNLGKCNEVVDFVTKDGYASESEAEDDEQSHVVLAQTL 255
            :::||..||.::|:|:::.      .:|||....::.|:....|..|:||.|.|:| .|.|.|.:
Worm   226 AIRVVASGLNKSVKKLMQAEKTMGKNIPNLSTYKDISDYFLNPGQLSDSEFEGDQQ-EVELPQDI 289

  Fly   256 -KSKGNLEDKKSSIKLHEIGPRLTMQLIKIEEGLLTGEVLYHDHVVKTEDEKETLRKLVEKKRKQ 319
             :.:|....:||:::|||||||||::|:|||||:..||||||.|..||.||...||..::||::.
Worm   290 SEGRGCGVGQKSNVRLHEIGPRLTLELVKIEEGIDEGEVLYHKHNAKTPDELIKLRAHMDKKKQM 354

  Fly   320 KEQRKKEQAENRARNLKLKKDEKWA----AKRAAEGRTDSDPEDDAEYYKEEVGEEPDEELFKME 380
            |::|::|..:...|.|.:.|:::.|    .|...|...........:..:.|..:|.|.|: .|.
Worm   355 KKRREQESEQRVIRRLTIVKEQQDAEEAEVKAIRENAARKQAAATGQVEEVENQKEKDREI-AMN 418

  Fly   381 AKSSRKRPSLGGGMKYKNKRAKLD 404
            .:...||.:...|....:||.:.:
Worm   419 RERDLKRANEEWGTSEASKRPRYE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppan	NP_476979.1	Brix	31..212	CDD:214879	75/182 (41%)
ppan	NP_476979.1	Brix	<215..295	CDD:294606	35/86 (41%)
lpd-6	NP_491108.2	Brix	59..229	CDD:214879	70/170 (41%)
		Brix	<302..375	CDD:382294	35/72 (49%)
		PTZ00121	<315..>443	CDD:173412	40/129 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156449
Domainoid	1	1.000	193	1.000	Domainoid score	I1877
eggNOG	1	0.900	-	-		E1_KOG2963
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I1911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004323
OrthoInspector	1	1.000	-	-		oto19006
orthoMCL	1	0.900	-	-		OOG6_101976
Panther	1	1.100	-	-	LDO	PTHR12661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1766
SonicParanoid	1	1.000	-	-		X3054
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.820