Protein Alignment Rab11 and RAB1B

DIOPT Version :10

• Sequence 1: NP_477170.1
• Gene: Rab11 / 42501
• FlyBaseID: FBgn0015790
• Length: 214
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 102/208 - (49%)
• Similarity: 136/208 - (65%)
• Gaps: 11/208 - (5%)

  Fly     7 EYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIEVDGKTIKAQIWDTAGQE 71
            |||||||::||||||||||.||.||..:.:.....|||||:|..|:||:||||||.|||||||||
Human     4 EYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQE 68

  Fly    72 RYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLRELRDHADQNIVIMLVGNKSDLRHLRSVPT 136
            |:|.|||:|||||.|.::|||:....:|.||::||:|:..:|.:|:..:||||||||...:.|..
Human    69 RFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDN 133

  Fly   137 DEAKLFAERNGLSFIETSALDSTNVETAFQNILTEIYRIVSQKQIRDPPEGDVIRPS-NVEPIDV 200
            ..||.||:..|:.|:||||.::||||.||..:..||     :|::.........||: .::...|
Human   134 TTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEI-----KKRMGPGAASGGERPNLKIDSTPV 193

  Fly   201 KPTVTADVRKQCC 213
            ||....     ||
Human   194 KPAGGG-----CC 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab11	NP_477170.1	Rab11_like	9..173	CDD:206660	91/163 (56%)
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	91/169 (54%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		5/14 (36%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		15/18 (83%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		11/14 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		5/31 (16%)