Protein Alignment Rab11 and RAB5A

DIOPT Version :10

• Sequence 1: NP_477170.1
• Gene: Rab11 / 42501
• FlyBaseID: FBgn0015790
• Length: 214
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 83/203 - (40%)
• Similarity: 126/203 - (62%)
• Gaps: 11/203 - (5%)

  Fly    12 FKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIEVDGKTIKAQIWDTAGQERYRAI 76
            ||:||:|:|.||||:|:.||.:.:|:...:||||..|.|:::.:|..|:|.:||||||||||.::
Human    21 FKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSL 85

  Fly    77 TSAYYRGAVGALLVYDIAKHLTYENVERWLRELRDHADQNIVIMLVGNKSDLRHLRSVPTDEAKL 141
            ...|||||..|::||||....::...:.|::||:..|..||||.|.|||:||.:.|:|...||:.
Human    86 APMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQS 150

  Fly   142 FAERNGLSFIETSALDSTNVETAFQNILTEIYRIVSQKQIRDPPEGDVIRPSNVEPIDV-KPTVT 205
            :|:.|.|.|:||||..|.||        .||:..:::|..::.|:......:....:|: :|  |
Human   151 YADDNSLLFMETSAKTSMNV--------NEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEP--T 205

  Fly   206 ADVRKQCC 213
            ...|.|||
Human   206 QPTRNQCC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab11	NP_477170.1	Rab11_like	9..173	CDD:206660	73/160 (46%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	75/168 (45%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		5/11 (45%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		9/15 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		8/35 (23%)