Protein Alignment rtet and QDR1

DIOPT Version :10

• Sequence 1: NP_524429.1
• Gene: rtet / 42500
• FlyBaseID: FBgn0028468
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_012146.1
• Gene: QDR1 / 854686
• SGDID: S000001382
• Length: 563
• Species: Saccharomyces cerevisiae
• Alignment Length: 539
• Identity: 116/539 - (21%)
• Similarity: 199/539 - (36%)
• Gaps: 145/539 - (26%)

  Fly     6 SRHNGTAAMEKQSHSQTGSHHHNNNKALDKEASENGKP----EKSDPMIYIIFVSL--LFDLLAF 64
            |.:|........:.|...:...|::..:|.|::.:..|    .....|:.::..:.  .|..:|.
Yeast    22 SDNNNVDRSSSDAISDNDAERSNSHSEIDNESNFDMVPYSRFSHKQKMLLVVQCAFTGFFSTVAG 86

  Fly    65 TIILPLLPSLLEHYRQNDSSGLYAVLTDRVRWFQQLLGAPDRYISVLFGGFLGSMFSFLQFVASP 129
            :|..|:|..:...:...:......::                            ::...|.||..
Yeast    87 SIYYPVLTIIERKFNITEELANVTIV----------------------------VYFIFQGVAPS 123

  Fly   130 IVGGLSDYYGRKPVLLACASGIALSYLIWACSSNFALFVLARFV--GGISKGNISLCMSVITDVS 192
            |:|||:|.:||:|::|........:.:..||:.|:|..:..|.:  .|||. .|::...::.||:
Yeast   124 IMGGLADTFGRRPIVLWAILAYFCACIGLACAHNYAQILALRCLQAAGISP-VIAINSGIMGDVT 187

  Fly   193 SVKTRGRGMALVGVAFSLGF-IVGPMIGALF-AIFSDKSGSTWFVLPSLLAFGLAVGDLVVLACC 255
            :...||..:.||.     || :||...|||. |..|.|.|  |..:...||.|..:       |.
Yeast   188 TKVERGGYVGLVA-----GFQVVGTAFGALIGAGLSSKWG--WRAIFWFLAIGSGI-------CL 238

  Fly   256 LRETL--PKEKRVKEISSALSYGLQLLNFSAIFRFAAIKNV------------PKKDIAALRSIG 306
            :..||  |:.||.. :.:........||.|.|....::|..            |:..:..|..:.
Yeast   239 VFSTLLMPETKRTL-VGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRTSVDFLAPLK 302

  Fly   307 LVYFL---YLFLYSGLEFT--------VTFLMYHKFGYTSMDQAKMFLTTGVIMTLLQGSVV--- 357
            :::..   .|...:||:|:        :|.::..|:..:.......||..| |.||.  |::
Yeast   303 ILHIREIDILLSIAGLQFSTWTTHQTALTIVLSKKYNLSVAKIGLCFLPAG-ISTLT--SIISAG 364

  Fly   358 ---------------RRLPE------AKIKG--------------YAIFSLY--LIVPAFVVVGL 385
                           |.:.|      .|.||              || |:|.  .:.||||.:.|
Yeast   365 RYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNSHYA-FNLVEARLHPAFVTLLL 428

  Fly   386 AEGSRMLYAGMTLF----AISTAF-AVTCLTTLVSKYGNDDQKGS---VLGIFRSLGALARALGP 442
            :.      .|.|.|    ::.|.. ||.|.:...|.:.|.....|   ::.:|.|..:.|
Yeast   429 SS------IGFTAFGWCISVKTPLAAVLCTSAFASLFSNCILTFSTTLIVDLFPSKASTA----- 482

  Fly   443 VVGCI-AFWCVGSRITYIA 460
             .||: .|.|:.|.| :||
Yeast   483 -TGCLNLFRCLLSAI-FIA 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rtet	NP_524429.1	MFS_MFSD10	50..476	CDD:340947	108/491 (22%)
QDR1	NP_012146.1	MFS_Tpo1_MDR_like	72..516	CDD:340881	108/489 (22%)