Protein Alignment Sec15 and SEC15

DIOPT Version :10

• Sequence 1: NP_650942.1
• Gene: Sec15 / 42499
• FlyBaseID: FBgn0266674
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_011281.1
• Gene: SEC15 / 852618
• SGDID: S000003202
• Length: 910
• Species: Saccharomyces cerevisiae
• Alignment Length: 861
• Identity: 159/861 - (18%)
• Similarity: 330/861 - (38%)
• Gaps: 183/861 - (21%)

  Fly     6 VQDIEAVD-DYWGPTFRSILEGNNTKQIGDQLEQRIRSHDK--EIERICNLYYQGFID-SIQELL 66
            |.|::.:. |.|.|..|..|:.|....:.|:||..|..:.:  |::.:.:......:: ||.|:.
Yeast    53 VFDLDPLSFDKWVPFLRRALDKNQLDPVIDELENSIEDNFQGLELQLLQDSQMNDKLETSIDEIA 117

  Fly    67 QVRTQAQQ-LHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKF 130
            .::...|. |.:|:......|.:.:..||.:....|..::|...::.|...:...:..||...|.
Yeast   118 NIQGMVQDTLSSEISKFQIRLSESANELIVKKQMYVNNKKISLKISEATILITKVVRILELSSKC 182

  Fly   131 TQQAKNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKE-------NIRRSS----- 183
            .:....:::::.|:.|::||..:|...|.:|::|..::...||.:::       |:.|:|
Yeast   183 QELITERKFFKVLQNLDSLEKLYLQEFKNYNFQFLIEIYNSIPFLQKVTKDECINLIRNSLNLNL 247

  Fly   184 -------ASDFREFLEN--IRKFSPRIGELAITHTKQLQKRDINAIIAEHMQQMNGGEAGGAGAG 239
                   ..:|....||  :.::.....::.:|:.|.....:|:......:.::|.||.
Yeast   248 GKNLIKVGQEFVAIYENELLPQWLETRSKMKLTNFKFNSPIEISMRDESFLAKLNLGEF------ 306

  Fly   240 GDDDGANVSAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLV--------------- 289
                   ....|..|...|::.|:...||...  |.|:|..::   .||:
Yeast   307 -------FQLDDFHDSIMIFQNLNELSVLSGE--FNKEYELRK---TKLMYPLIWKKNKTAAYQM 359

  Fly   290 --------LQPPPNMHD-----------NLEAYKTYICAIVGFFVVEDHV-KNTAGDVVTSSY-- 332
                    ..|....||           :|...:.|...|:||.:.:.:: |.|...:|.::|
Yeast   360 DSLLRGTGTTPGSTAHDVSTDDPFTQSLSLHFLQDYFLKILGFLLYDINLNKATEFILVDNNYNS 424

  Fly   333 -------LEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCYGYTVNILWELLH 390
                   |.|..|..|:.|::|...:...      ::::|:.:.:.:...:.:...:..|:::|.
Yeast   425 TNEFWDGLMDRLSPYLSYFIDEKLKTEED------MIKLKDFLCIYVAILENFKLNIEPLYKILV 483

  Fly   391 NMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIE----------RFPFHSEQLENA 445
            ::.:.:..|.|:.:...|:.:|:.:.|:|:.:.:...||.:::          ..|   :.....
Yeast   484 SIFEKFCSVSLRAFDDEFQILLNDDDFMPLSINDKTLYEKVLKICWMKEGEHLSLP---DPTNGE 545

  Fly   446 PFPKKFPFSRMVP-------EVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSG 503
            ||....|||.:.|       :.|.:...|:  .:.:..||....|.:...:....|.::.:....
Yeast   546 PFAVTLPFSPLYPMTCTLAKKTYSKITAFL--SIFYRHELHTLNNILVKTMDDIFNDIVNKKIRS 608

  Fly   504 CLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTP------SAMFHVA- 561
            .|....|:      ::.||:::..|...|......|:     |..::.|.|      |::.::|
Yeast   609 KLESTSRE------EIAQILVNLDYFIIAAKEFSNFM-----TRENILQNPDMEIRLSSIKYLAE 662

  Fly   562 -RQDAEKQVGLRICSKIDEFFELSAYDWLLVE---PPGIASAFITDMISYLKSTFDSFAFKLPHI 622
             |:.||.::...|.|||.:..|....||.:.|   .|.|:   |.|:..:|:..|.|....||:.
Yeast   663 SRKLAETKLIELIDSKISDILETIEIDWQITEVRQDPDIS---IIDLAQFLEMMFASTLQNLPYS 724

  Fly   623 AQA-ACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEF------------------- 667
            .|. ...|.|:.:..:...::..:....|:..::....:|:...|.
Yeast   725 VQTLLIFREFDSLTRQFMGLLLHDTPSTITHESIMNFEVDVNYLESIIPRIFPSTPGTIDSNGYQ 789

  Fly   668 --FAASEP---------VPGLKEG---ELSKYFLRNRQLLDLLILEEWSTYFHDYGKQE---NRY 715
              ...|.|         .|.|.|.   .|...|:..:|.::||     .|...||.:.|   .:|
Yeast   790 SPMTPSTPTFPNANGVDAPTLFENNIKSLEATFMELKQCIELL-----KTQGKDYNEPEIRLRKY 849

  Fly   716 HLVQPQSIIVILEKIR 731
            ..::.:...::|.||:
Yeast   850 SRIRQEDAALLLSKIQ 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:461169	69/366 (19%)
SEC15	NP_011281.1	Sec15	521..864	CDD:461169	69/366 (19%)