DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and exoc6b

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_021333284.1	Gene:	exoc6b / 767763	ZFINID:	ZDB-GENE-060929-132	Length:	816	Species:	Danio rerio

Alignment Length:	806	Identity:	336/806 - (41%)
Similarity:	498/806 - (61%)	Gaps:	50/806 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQDIEAVD-DYWGPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVR 69
            :::||:.| :..|||.||:.:|.......::||.|||:||:|||::||.::|||:|||.|||:||
Zfish    14 LREIESTDTNCIGPTLRSVYDGQEHGLFMEKLEGRIRNHDREIEKMCNHHFQGFVDSITELLKVR 78

  Fly    70 TQAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQA 134
            .:||:|..:|...:..|:.....|:...|:|.:.|..:.|:|:.|:.|..|||.||.|.|..:|.
Zfish    79 GEAQKLKGQVTETNQKLQNDGKELLTSMNELRQCRVQQRNIATTIDKLTHCLPVLEMYSKLQEQM 143

  Fly   135 KNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSP 199
            :.|:||.||||||.||...|.  :..:|||.|.|...||.::.:||..|.||.::|||:|||.|.
Zfish   144 RAKRYYPALRTLEQLEESCLP--QAGSYRFCTIMAENIPRLRTHIRDVSMSDLKDFLESIRKHSD 206

  Fly   200 RIGELAITHTKQLQKRDINAIIAEHMQQMNGGEAGGAGAGG---DDDGAN--------------- 246
            :|||.|:...:....|| ||:.:: .:..:|......|.|.   |..|.|
Zfish   207 KIGETAMKQAQVQIARD-NAVTSQ-QRSASGRRIRKEGYGSTEVDRTGNNPFSEQDSGILDVDDE 269

  Fly   247 -----VSAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTY 306
                 ..|.||:||||:|||||||.|||.|:.||..||:|||.||:|||||..|||:.||.|:.|
Zfish   270 QEEEVPGAHDLVDFSPVYRCLHIYTVLGARDTFENYYRKQRRKQARLVLQPHSNMHETLEGYRRY 334

  Fly   307 ICAIVGFFVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLS 371
            ...||||||||||:.:|...:|..:|:|:||..:|:|.:..:...||.||||:::|.:||||:|.
Zfish   335 FNQIVGFFVVEDHILHTTQGLVNRAYVEELWELALSKTIAALRTHSSYCTDPDLVLDLKNLIVLF 399

  Fly   372 INTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFP 436
            .:|.:.||:.||.|:::|..|||.|.|:||::|...||:|||::.:.|:.|.:.|||:.|..:||
Zfish   400 ADTLQGYGFPVNQLFDMLLEMRDQYGEILLKKWSQSFRQILDQDNYSPIPVVSPEEYQRITGQFP 464

  Fly   437 FHSEQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSF 501
            |...:|:..|||||.|||..||:||.|.|||:|||:|::|:|.||..|:..|:||:.||||||:.
Zfish   465 FQDPELDKMPFPKKLPFSEFVPKVYSQLKEFIYACLKYSEDLHLSSTEIDDMIRKSTNLLLTRTL 529

  Fly   502 SGCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTN----TERSVSQTPSAMFHVAR 562
            |.||....::.::.|.:|:||||:|.:||::..:|:||:.::||    |..:.....::.|..||
Zfish   530 SHCLQYAIKKKNVGLAELVQIIINTTHLEQSCHYLEEFISNITNVPPDTINATKLYGTSTFKDAR 594

  Fly   563 QDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAF---------K 618
            ..||:::...:..|||:|.:|:.|||...:..|.||.:::|:|::|.|||..|..         .
Zfish   595 HAAEEEIYTNLNQKIDQFLQLADYDWTAAQGGGQASDYLSDLIAFLCSTFAVFTHLPGNAIEHAT 659

  Fly   619 LP-HIAQAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGEL 682
            || .:||.||....:|::..:..::.:.||:|:|.|||.|.|:|:.:||.||.:.||||.:...|
Zfish   660 LPGKVAQTACMSACKHLSTSLLQLLLEADVRQVSMGALQQFNVDVKECERFARAGPVPGFQGDTL 724

  Fly   683 SKYFLRNRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKIRE-----ADKKPIFSLV 742
            ...|:..||||||....:||||..|||:...:|..|.|.:.:.:||||..     :.|..:|:..
Zfish   725 LLAFIDLRQLLDLFTQWDWSTYLADYGRPTCKYLRVNPHTALALLEKISRSMKDTSRKNNMFAQF 789

  Fly   743 RKN--DKKKLLETVLKQLKH-IADRQ 765
            |||  ||:||::||:|||:: ||..|
Zfish   790 RKNERDKQKLIDTVVKQLRNLIASNQ 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	126/315 (40%)
exoc6b	XP_021333284.1	Sec15	456..772	CDD:309285	126/315 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44781
Inparanoid	1	1.050	634	1.000	Inparanoid score	I807
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm24610
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	LDO	PTHR12702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980