Protein Alignment Sec15 and EXOC6

DIOPT Version :10

• Sequence 1: NP_650942.1
• Gene: Sec15 / 42499
• FlyBaseID: FBgn0266674
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001306123.1
• Gene: EXOC6 / 54536
• HGNCID: 23196
• Length: 820
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 319/779 - (40%)
• Similarity: 487/779 - (62%)
• Gaps: 46/779 - (5%)

  Fly    19 TFRSILEG--NNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVRTQAQQLHNEVHS 81
            |.||:.:.  |..|:..::|:..||:||||||::||.::|||:|:|.|||:|||.|::|..:|..
Human    48 TLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTD 112

  Fly    82 LDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAKNKQYYQALRTL 146
            .:...:.....:|....|::|.|..:.|:.:.:|.|:.|||.||.|.|..:|...|:||.||:|:
Human   113 TNRRFQDAGKEVIVHTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKTM 177

  Fly   147 ETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSPRIGELAI----- 206
            |.||..:...:.  .|||...|...:|.::|:|:..|.||.::|||:|||.|.:|||.|:
Human   178 EQLENVYFPWVS--QYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQH 240

  Fly   207 --THTKQLQKR------------------DINAIIAEHMQQMNGGEAGGAGAGGDDDGANVSAQD 251
              |.:..|||:                  :.|..:.:|..:..          .:::...::.||
Human   241 QKTFSVSLQKQNKMKFGKNMYINRDRIPEERNETVLKHSLEEE----------DENEEEILTVQD 295

  Fly   252 LIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGFFVV 316
            |:||||:|||||||.|||..|.||..||:||:.||:|||||..|||:.::.|:.|...|||||||
Human   296 LVDFSPVYRCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVV 360

  Fly   317 EDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCYGYT 381
            |||:.:....:||.:|.::||:.:|:|.:..:...||.||||:::|.:|||.::..:|.:.||:.
Human   361 EDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLTVIFADTLQGYGFP 425

  Fly   382 VNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHSEQLENAP 446
            ||.|::||..:||.|||.||::|..|||:|.:::.:.|:.|.|.|||:.:|.:|||....||...
Human   426 VNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPVVNEEEYKIVISKFPFQDPDLEKQS 490

  Fly   447 FPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSGCLSVVFRQ 511
            ||||||.|:.||.:|.|.|||:||.:||:|.|..|..|:..|:||:.||||||:.|.||..:.|:
Human   491 FPKKFPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIRK 555

  Fly   512 PSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTPS----AMFHVARQDAEKQVGLR 572
            |.|.||:|:||||:|.:||:|..:|::|:.::||..:....|..    :.|..||..||.::..:
Human   556 PHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTK 620

  Fly   573 ICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPHIAQAACRRTFEHIAEK 637
            :..|||||.:|:.|||.:.||.|.||.::.|:|::|:|.|..|......:||.||....:|::..
Human   621 LNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTS 685

  Fly   638 IYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLRNRQLLDLLILEEWS 702
            :..::.|.::||||.||:.|.|||::|||.||:||||||.:...|...|:..||||||.::.:||
Human   686 LMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWS 750

  Fly   703 TYFHDYGKQENRYHLVQPQSIIVILEKIREADKK-PIFSLVRKN--DKKKLLETVLKQLKHIAD 763
            ||..|||:..::|..|.|.:.:.:|||:::..|| .||:..|||  ||:||:|||:|||:.:.:
Human   751 TYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVN 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:461169	132/305 (43%)
EXOC6	NP_001306123.1	Sec15	472..778	CDD:461169	132/305 (43%)