DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and Exoc6b

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_038964085.1	Gene:	Exoc6b / 500233	RGDID:	1560638	Length:	814	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	338/788 - (42%)
Similarity:	499/788 - (63%)	Gaps:	36/788 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQDIEAVDDYW-GPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVR 69
            :::||:.|... |||.||:.:|....:..::||.|||:||:|||::||.:||||:|||.|||:||
  Rat    21 LREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVR 85

  Fly    70 TQAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQA 134
            .:||:|.|:|...:..|:.....|:....:|.:.|..:.|:::.::.|..|||.||.|.|...|.
  Rat    86 GEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQM 150

  Fly   135 KNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSP 199
            |.|::|.||:|||.||..:|.::.  :|||...|...||.::|.|:..|.||.::|||:|||.|.
  Rat   151 KTKRHYPALKTLEHLEHTYLPQVS--HYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSD 213

  Fly   200 RIGELAITHTKQ--------LQ----------KRDINAIIAEHMQQMNGGEAGGAG----AGGDD 242
            :|||.|:...:|        ||          |:|:..|....::..:......:|    ...:|
  Rat   214 KIGETAMKQAQQQRNLDNIVLQQPRLGSKRKSKKDVYTIFDTEVESTSPKSEQDSGILDVEDEED 278

  Fly   243 DGANVSAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYI 307
            |.....||||:||||:|||||||.|||.||.||..||:|||.||:||||||.|||:.|:.|:.|.
  Rat   279 DEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYF 343

  Fly   308 CAIVGFFVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSI 372
            ..||||||||||:.:|...:|..:|:::||..:|:|.:..:...||.|:|||::|.:||||:|..
  Rat   344 NQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFA 408

  Fly   373 NTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPF 437
            :|.:.||:.||.|:::|..:||.|:|.||::|..|||.|||.:.:.|:.|.:.|.|:.::.:|||
  Rat   409 DTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPF 473

  Fly   438 HSEQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFS 502
            ...:||..|||||||||..||:||:|.|||:|||:||:|:|.||..||..|:||:.||||||:.|
  Rat   474 QDTELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLS 538

  Fly   503 GCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTN----TERSVSQTPSAMFHVARQ 563
            ..|..|.::.:|.||:|:||||:|.:|||:..:|:||:.::||    |..:.....:..|..||.
  Rat   539 NSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARH 603

  Fly   564 DAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPHIAQAACR 628
            .||:::...:..|||:|.:|:.|||:..|....||.::.|:|::|:|||..|......:||.||.
  Rat   604 AAEEEIYTNLNQKIDQFLQLADYDWMTGELDNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACM 668

  Fly   629 RTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLRNRQLL 693
            ...:|:|..:..::.:.:|:|::.|||.|.|||:.:||.||.|.||||.:|..|...|:..||||
  Rat   669 SACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLL 733

  Fly   694 DLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKI-RE----ADKKPIFSLVRKN--DKKKLL 751
            ||.|..:||||..|||:...:|..|.|.:.:.:|||| ||    :.|..:|:..|||  ||:||:
  Rat   734 DLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKISREMKDTSRKNNMFAQFRKNERDKQKLI 798

  Fly   752 ETVLKQLK 759
            :||.|||:
  Rat   799 DTVAKQLR 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	133/305 (44%)
Exoc6b	XP_038964085.1	SCP-1	<2..>266	CDD:114219	91/246 (37%)
Exoc6b	XP_038964085.1	Sec15	464..770	CDD:397972	133/305 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I983
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44781
Inparanoid	1	1.050	632	1.000	Inparanoid score	I806
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm44634
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	LDO	PTHR12702
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980