DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and exoc6

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_021335720.1	Gene:	exoc6 / 406591	ZFINID:	ZDB-GENE-040426-2511	Length:	826	Species:	Danio rerio

Alignment Length:	794	Identity:	324/794 - (40%)
Similarity:	503/794 - (63%)	Gaps:	42/794 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DIEAVDDYWGPTFRSILEG--NNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVRT 70
            ::|:||...|.:.||:.:.  |..|:..::|:.|||:||:|||::||.::|||:|:|.|||:||.
Zfish    31 ELESVDLPLGTSLRSVYDDQPNAHKRFMEKLDARIRNHDREIEKMCNFHHQGFVDAITELLKVRA 95

  Fly    71 QAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAK 135
            .|::|..:|...:..|:.....:..|..:::|.|..:.|:|:.:|.|:.|:|.||.|.|..:|.:
Zfish    96 DAEKLMGQVSDTNRRLQDAGREVTAQTEEVIRCRVQQRNMATTVEKLQLCIPVLEMYSKLKEQLE 160

  Fly   136 NKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSPR 200
            :|:||.||:|:|.||..::.|:.  .|||...|...:|.::|.|:..|.||.::|||:|||.|.:
Zfish   161 SKRYYSALKTMEQLENIYIPRVS--QYRFCQIMAETLPKLREEIKEISMSDLKDFLESIRKHSDK 223

  Fly   201 IGELAITHTKQ-------LQKRDINAIIAEHMQQMNG-------GEAGGAGAGGDDDGANVSAQD 251
            |||.|:...:|       :||: :....|:.:..:||       |.:.......:.|...::|||
Zfish   224 IGETAMRQAQQHRTFNSAVQKQ-VTLSCAKPLYGLNGRTPLHHNGLSTDTAEEEEIDEEVLTAQD 287

  Fly   252 LIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGFFVV 316
            |:||||:|||||||.|||.||.||..||:||:.||:|||||..|||:.:|.|:.|...|||||||
Zfish   288 LVDFSPVYRCLHIYTVLGDRETFENYYRKQRKKQARLVLQPQSNMHETVEGYRKYFNQIVGFFVV 352

  Fly   317 EDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCYGYT 381
            |||:.:....:||.::.::||:.:|:|.:..:...||.|.||:::|.:||||::..:|.:.||:.
Zfish   353 EDHILHATQGLVTRAFTDELWNMALSKIIAVLRTHSSYCNDPDLVLELKNLIVIFADTLQGYGFP 417

  Fly   382 VNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHSEQLENAP 446
            ||.|::||..:||.|||.||::|..|||:|.:::.:.|:.|...|||:.::.|||||..::|...
Zfish   418 VNRLFDLLFEVRDQYNETLLKKWALVFRDIFEQDNYSPIPVDTEEEYKAVVSRFPFHDAEIEKQQ 482

  Fly   447 FPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSGCLSVVFRQ 511
            ||||.|.|:.||::|.|.|||:||.:||:|.|..|..|:..|:||:.||||||:.|.||..:.::
Zfish   483 FPKKLPMSQSVPQIYSQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLQNLIKK 547

  Fly   512 PSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTPS----AMFHVARQDAEKQVGLR 572
            |.|.||:|:||||:|.:||.|..:|::|:.::||.......|..    :.|..||..||.::..:
Zfish   548 PHIGLTELVQIIINTTHLEHACKYLEDFITNITNVSPETVHTTRLYGLSTFKDARHAAEGEIYTK 612

  Fly   573 ICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPH-----------IAQAA 626
            :..|||||.:|:.|:|.:.|..|.||.::.|:|::|:|||..|. .||:           :||.|
Zfish   613 LNQKIDEFIQLADYEWGMAESDGRASGYLMDLINFLRSTFQVFT-HLPNNNNDHAAMSGKVAQTA 676

  Fly   627 CRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLRNRQ 691
            |....:|:|..:..::.|.::||||.||:.|.|||::|||.||:||||||.:...|...|:..||
Zfish   677 CMSACKHLATSLMQMLLDTELKQISMGAIQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQ 741

  Fly   692 LLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKIRE-----ADKKPIFSLVRKN--DKKK 749
            ||||.::.:||||..|||:..::|..|.|.:.:.:|||:..     :.|..|||..|||  |::|
Zfish   742 LLDLFMVWDWSTYLADYGQPTSKYLRVNPSTALALLEKVNRGMKDTSKKNNIFSQFRKNDRDRQK 806

  Fly   750 LLETVLKQLKHIAD 763
            |:|||:|||:.:.:
Zfish   807 LIETVVKQLRSLVN 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	132/316 (42%)
exoc6	XP_021335720.1	I_LWEQ	<92..177	CDD:327626	29/84 (35%)
exoc6	XP_021335720.1	Sec15	464..780	CDD:309285	132/316 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595943
Domainoid	1	1.000	346	1.000	Domainoid score	I1011
eggNOG	1	0.900	-	-		E1_KOG2176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	634	1.000	Inparanoid score	I807
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm24610
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	O	PTHR12702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1305
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840