DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and EXOC6B

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001308658.1	Gene:	EXOC6B / 23233	HGNCID:	17085	Length:	815	Species:	Homo sapiens

Alignment Length:	793	Identity:	336/793 - (42%)
Similarity:	502/793 - (63%)	Gaps:	46/793 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQDIEAVDDYW-GPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVR 69
            :::||:.|... |||.||:.:|....:..::||.|||:||:|||::||.:||||:|||.|||:||
Human    22 LREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVR 86

  Fly    70 TQAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQA 134
            .:||:|.|:|...:..|:.....|:....:|.:.|..:.|:::.::.|..|||.||.|.|...|.
Human    87 GEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQM 151

  Fly   135 KNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSP 199
            |.|::|.||:|||.||..:|.::.  :|||...|...||.::|.|:..|.||.::|||:|||.|.
Human   152 KTKRHYPALKTLEHLEHTYLPQVS--HYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSD 214

  Fly   200 RIGELAITHTKQLQKRDINAIIAEHMQQMNGG--------------------------EAGGAGA 238
            :|||.|:...:  |:|:::.|:   :||...|                          ::|....
Human   215 KIGETAMKQAQ--QQRNLDNIV---LQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDV 274

  Fly   239 GGDDDGANV-SAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEA 302
            ..::|...| .||||:||||:|||||||.|||.||.||..||:|||.||:||||||.|||:.|:.
Human   275 EDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDG 339

  Fly   303 YKTYICAIVGFFVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNL 367
            |:.|...||||||||||:.:|...:|..:|:::||..:|:|.:..:...||.|:|||::|.:|||
Human   340 YRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNL 404

  Fly   368 IMLSINTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECII 432
            |:|..:|.:.||:.||.|:::|..:||.|:|.||::|..:||.|||.:.:.|:.|.:.|.|:.::
Human   405 IVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVV 469

  Fly   433 ERFPFHSEQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLL 497
            .:|||...:||..|||||||||..||:||:|.|||:|||:||:|:|.||..||..|:||:.||||
Human   470 GQFPFQDIELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLL 534

  Fly   498 TRSFSGCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTN----TERSVSQTPSAMF 558
            ||:.|..|..|.::.:|.||:|:||||:|.:|||:..:|:||:.::||    |..:.....:..|
Human   535 TRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTF 599

  Fly   559 HVARQDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPHIA 623
            ..||..||:::...:..|||:|.:|:.|||:..:....||.::.|:|::|:|||..|......:|
Human   600 KDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPGKVA 664

  Fly   624 QAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLR 688
            |.||....:|:|..:..::.:.:|:|::.|||.|.|||:.:||.||.|.||||.:|..|...|:.
Human   665 QTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFID 729

  Fly   689 NRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKI-RE----ADKKPIFSLVRKN--D 746
            .||||||.|..:||||..|||:...:|..|.|.:.:.:|||| ||    :.|..:|:..|||  |
Human   730 LRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKISREMKDTSRKNNMFAQFRKNERD 794

  Fly   747 KKKLLETVLKQLK 759
            |:||::||.|||:
Human   795 KQKLIDTVAKQLR 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	132/305 (43%)
EXOC6B	NP_001308658.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280		1/19 (5%)
EXOC6B	NP_001308658.1	Sec15	465..771	CDD:367808	132/305 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	349	1.000	Domainoid score	I1029
eggNOG	1	0.900	-	-		E1_KOG2176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44781
Inparanoid	1	1.050	627	1.000	Inparanoid score	I863
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm40492
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	LDO	PTHR12702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1305
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870