DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and sec-15

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_509496.3	Gene:	sec-15 / 181131	WormBaseID:	WBGene00016188	Length:	817	Species:	Caenorhabditis elegans

Alignment Length:	799	Identity:	290/799 - (36%)
Similarity:	460/799 - (57%)	Gaps:	47/799 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKVTVQDIEAVDDYW------------GPTFRSILEGNNTKQIGDQLEQRIRSHDKEIERICNLY 54
            |.|...::.|..:|:            |...|:|.:..:.:.....|:|||..:||.|:::|:.:
Worm    21 SYVNYVEMSAEQEYFLYELETTDSGSMGLVLRAIYDTGDVQSFARALQQRISHYDKNIQKVCSFH 85

  Fly    55 YQGFIDSIQELLQVRTQAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKS 119
            ||.|:|::|||::::.|.|.:..|..::|..::|||..|.|:..::||.|::..|..:|::.:..
Worm    86 YQSFVDAMQELMKLKEQCQDIKEETVAIDAEIQQISQRLCQKKQEIVRYRKLMKNAKTAMDQIAV 150

  Fly   120 CLPALECYMKFTQQAKNKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSA 184
            |||.||.|.|..:|..|::|||||:|||.||..||..::  .|||...:...:..::..|:..:.
Worm   151 CLPVLENYAKLQEQMSNRKYYQALKTLEELEHTHLALVE--KYRFTQVLAKSMAPVRLEIKEKAY 213

  Fly   185 SDFREFLENIRKFSPRIGELAITHTKQLQKRDI-NAIIAEHMQQMNGGEAGG----AGAGGD--- 241
            |:|::|||||:|.:.|||:.|...|.:.....: :|..|:.:|:.....|..    ..|.|.
Worm   214 SEFKDFLENIKKVAGRIGKHASKDTAEQHSFGVTDAERAKKIQEEARKNASNVEIEVSADGSIVK 278

  Fly   242 -------------DDGANVSAQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPP 293
                         :|...|||||||||:|::||..|:.|||.:|.||:.|||||::|..||::|.
Worm   279 KNMSPKRNMKMQVEDDEQVSAQDLIDFTPVHRCCQIFNVLGAKEEFEQYYRQQRKEQCDLVIEPT 343

  Fly   294 PNMHDNLEAYKTYICAIVGFFVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDP 358
            ..| :|.:.|..|:..|||||||||.:..|..::.|:...:.||.::|.|....:........|.
Worm   344 HKM-NNFKHYVEYLDEIVGFFVVEDQILMTQSNLSTTVDKDKLWDNALMKIRQHLDARFGGSPDV 407

  Fly   359 NILLRIKNLIMLSINTFKCYGYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQ 423
            .::|::|.:|:|.|.|.|.|||.|..|:|||.|.||.|||:|::.:...|...|:|:.:.|:.|.
Worm   408 LMMLKMKKVILLFILTMKSYGYAVAPLYELLQNFRDQYNEILVKEYCAQFERDLEKDNYTPITVN 472

  Fly   424 NTEEYECIIERFPFHSEQLENAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAM 488
            :.||:..||.:|||:...:|..|||::||||..|.:.|.|||.::..|:||.:.|.|:.:.|...
Worm   473 SEEEFRTIIRKFPFYKRSMEQEPFPRRFPFSPFVTDAYTQAKNYLIGCLKFMDNLQLNTSAVDDT 537

  Fly   489 VRKAANLLLTRSFSGCLSVVFRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQT 553
            ||:.||:||.| ::|.|. .|....:::.||:||.|:..||||:...|..|:...|:.|.::..|
Worm   538 VRRCANVLLGR-WAGVLK-SFVHKRLSMIQLVQITINLGYLEKSCESLGAFITSKTSGEEAIGTT 600

  Fly   554 ------PSAMFHVARQDAEKQVGLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTF 612
                  ...:|...|.:.|:|:...:.||:||..:|:.|||.|....|.||.||:|:|::|::||
Worm   601 SHQVVLSEKVFRDVRSEVEQQIDECMRSKVDEIIDLANYDWELPAAAGQASEFISDLINFLQTTF 665

  Fly   613 DSFAFKLPH-IAQAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPG 676
            .||. .||. :|:..|.:|.:||::.:...:...:.|.||||||.|.:||:||||.|....||.|
Worm   666 TSFT-NLPSGLAKHVCTQTCKHISQSMSDFLLSPETKCISTGALDQFSLDVMQCEMFTTRCPVAG 729

  Fly   677 LKEGELSKYFLRNRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKIREADKKPI-FS 740
            :....||..|...||||||::..:|:|:..:|||...:|..|:..:.||:|||:.|.::|.. |.
Worm   730 VDPQTLSMTFADLRQLLDLVMSSDWTTFNAEYGKDHAKYLRVKASTAIVVLEKMIEFERKSTGFF 794

  Fly   741 LVRKNDKKKLLETVLKQLK 759
            .:.|.|:||||:|:::|||
Worm   795 GIAKGDRKKLLDTIVRQLK 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	118/308 (38%)
sec-15	NP_509496.3	Sec15	477..783	CDD:282011	118/308 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167259
Domainoid	1	1.000	220	1.000	Domainoid score	I1504
eggNOG	1	0.900	-	-		E1_KOG2176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44781
Inparanoid	1	1.050	507	1.000	Inparanoid score	I723
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		oto17701
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	LDO	PTHR12702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1305
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800