DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and Exoc6

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_017173533.1	Gene:	Exoc6 / 107371	MGIID:	1351611	Length:	811	Species:	Mus musculus

Alignment Length:	775	Identity:	316/775 - (40%)
Similarity:	485/775 - (62%)	Gaps:	46/775 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TFRSILEG--NNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVRTQAQQLHNEVHS 81
            |.||:.:.  |..|:..::|:..||:||||||::||.::|||:|:|.|||:||..|::|..:|..
Mouse    39 TLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRADAEKLKVQVTD 103

  Fly    82 LDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAKNKQYYQALRTL 146
            .:...:.....:|.|..|::|.|..:.|:.:.:|.|:.|||.||.|.|..:|...|:||.||:|:
Mouse   104 TNRRFQDAGKEVIIQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSMKRYYSALKTM 168

  Fly   147 ETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSPRIGELAITHTKQ 211
            |.||..:..|:.  .|||...|...:|.::|:|:..|.||.::|||:|||.|.:|||.|:...:|
Mouse   169 EQLENVYFPRVS--QYRFCQLMMETLPKLREDIKDISMSDLKDFLESIRKHSDKIGEAAMKQAQQ 231

  Fly   212 -------LQKRD---------IN---------AIIAEHMQQMNGGEAGGAGAGGDDDGANVSAQD 251
                   |||::         :|         .:|.:|..:..          .::|...::.||
Mouse   232 QKSFSVALQKQNNMRFGKNMHVNNDRILEEKSDVIPKHALEEE----------AENDEEVLTVQD 286

  Fly   252 LIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGFFVV 316
            |:||||:|||||||..||..|.||..||:||:.||:|||||..::|:.::.|:.|...|||||||
Mouse   287 LVDFSPVYRCLHIYSALGDEETFENYYRKQRKKQARLVLQPQSSVHETVDGYRRYFTQIVGFFVV 351

  Fly   317 EDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCYGYT 381
            |||:.:....:||..|.|:||:.:|:|.:..:...||.||||:::|.:||||::..:|.:.||:.
Mouse   352 EDHILHVTQGLVTRVYTEELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFP 416

  Fly   382 VNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHSEQLENAP 446
            ||.|::||..:||.|||.||::|..:||:|.:::.:.|:.:.:.|||:.:|.||||....||...
Mouse   417 VNRLFDLLFEIRDQYNETLLKKWAGIFRDIFEEDNYSPIPIGSEEEYKVVISRFPFQDPDLEKQS 481

  Fly   447 FPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSGCLSVVFRQ 511
            ||||||.|:.||.:|.|.|||:||.:||:|.|..|..|:..|:||:.||||||..|.||..:.|:
Mouse   482 FPKKFPMSQSVPLIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRILSSCLLNLIRK 546

  Fly   512 PSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTPS----AMFHVARQDAEKQVGLR 572
            |.|.||:|:||||:|.:||:|..:|::|:.::||..:....|..    :.|..||..||.::..:
Mouse   547 PHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTK 611

  Fly   573 ICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPHIAQAACRRTFEHIAEK 637
            :..|||||.:|:.|||.:.|..|.||.::.|:|::|:|.|..|......:||.||....:|::..
Mouse   612 LNQKIDEFVQLADYDWTMAESDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTS 676

  Fly   638 IYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLRNRQLLDLLILEEWS 702
            :..::.|.::||||.||:.|.|||::|||.||:||||||.:...|...|:..||||||.::.:||
Mouse   677 LMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWS 741

  Fly   703 TYFHDYGKQENRYHLVQPQSIIVILEKIREADKK-PIFSLVRKN--DKKKLLETVLKQLK 759
            ||..|||:..::|..|.|.:.:.:|||:::..|| .||:..|||  |::||:|||::||:
Mouse   742 TYLADYGQPASKYLRVNPHAALTLLEKMKDTSKKNNIFAQFRKNDRDRQKLIETVVRQLR 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	132/305 (43%)
Exoc6	XP_017173533.1	Sec15	463..769	CDD:367808	132/305 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850094
Domainoid	1	1.000	351	1.000	Domainoid score	I1013
eggNOG	1	0.900	-	-		E1_KOG2176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I847
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54879
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm42566
orthoMCL	1	0.900	-	-		OOG6_101663
Panther	1	1.100	-	-	O	PTHR12702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1305
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800