DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec15 and exoc6

DIOPT Version :9

Sequence 1:	NP_650942.1	Gene:	Sec15 / 42499	FlyBaseID:	FBgn0266674	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_031761799.1	Gene:	exoc6 / 100490668	XenbaseID:	XB-GENE-1013433	Length:	821	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	322/793 - (40%)
Similarity:	496/793 - (62%)	Gaps:	43/793 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DIEAVDDYWGPTFRSILEG--NNTKQIGDQLEQRIRSHDKEIERICNLYYQGFIDSIQELLQVRT 70
            :||.::...|.|..|:.:.  |..::..::|:.|||:||:|||::||.::|||:::|.|||:||.
Frog    29 EIETLELPLGTTLSSVYDDQPNAHQRFMEKLDARIRNHDREIEKMCNFHHQGFVEAINELLKVRA 93

  Fly    71 QAQQLHNEVHSLDTSLRQISASLIQQGNDLVRARQIESNLASAIEALKSCLPALECYMKFTQQAK 135
            .|::|..:|...:..|:.....:|.:..:.:|.|..:.|:|:.|:.|:.||||||.|.|..:|..
Frog    94 DAEKLKVQVTDTNRRLQDAGKEVIAKTEESIRCRIQQRNIATVIDKLQLCLPALEMYSKLKEQIS 158

  Fly   136 NKQYYQALRTLETLETEHLTRLKTHNYRFATQMQIQIPIIKENIRRSSASDFREFLENIRKFSPR 200
            .|:||.||:|:|.||..:|.  |...|||...|...:|.::|.|:..|.|..::|||:|||.|.:
Frog   159 GKRYYSALKTMEQLENIYLP--KVSQYRFCQIMGENLPKLREEIKEISMSGLKDFLESIRKHSDK 221

  Fly   201 IGELAITHTKQ-------LQKRD----------INAIIAEHMQQMNGGEAGGAGAGGDDDGANVS 248
            |||.|:...:|       |.|:.          :|..|:|   ..||.::....|..|.:...::
Frog   222 IGETAMRQAQQQKTFQVALHKKTNVSLKKTKYILNGHISE---DKNGVKSKYDAADEDTEEEVLN 283

  Fly   249 AQDLIDFSPIYRCLHIYMVLGQREYFEKDYRQQRRDQAKLVLQPPPNMHDNLEAYKTYICAIVGF 313
            .|||:||||:|||||||.:||.:|.||..||:|||.||:|||||...||:.:|.|:.|...|.||
Frog   284 VQDLVDFSPVYRCLHIYSILGDKEVFENYYRKQRRKQARLVLQPQSTMHETVEGYRKYFSQIAGF 348

  Fly   314 FVVEDHVKNTAGDVVTSSYLEDLWSSSLTKFVNEISMSSSSCTDPNILLRIKNLIMLSINTFKCY 378
            ||||||:.:....:||.||..:||:.:.:|.:..:...||.||||:::|.:||||::..:|.:.:
Frog   349 FVVEDHILHVTQGLVTGSYTTELWNMAQSKIIAVLRTHSSYCTDPDLVLELKNLIVVFADTMQGF 413

  Fly   379 GYTVNILWELLHNMRDHYNEVLLQRWVHVFREILDKEQFLPMVVQNTEEYECIIERFPFHSEQLE 443
            |:.|..|::||..:||.|||.||::|..:||.|.:.:.:.|:.:.|.|||..:|.:|||...:.:
Frog   414 GFPVTRLFDLLFEVRDRYNETLLKKWAGIFRTIFEADNYSPIPIANEEEYRIVISKFPFQDAETD 478

  Fly   444 NAPFPKKFPFSRMVPEVYHQAKEFMYACMKFAEELTLSPNEVAAMVRKAANLLLTRSFSGCLSVV 508
            ..|||||.|.|:.||::|.|.|||:||.:||:|.|..|..|:..|:||:.||||||:.|..|..|
Frog   479 KKPFPKKLPVSQSVPQIYSQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSSLQNV 543

  Fly   509 FRQPSITLTQLIQIIIDTQYLEKAGPFLDEFVCHMTNTERSVSQTPS----AMFHVARQDAEKQV 569
            .::|.|.||:|:||||:|.:||:|..:|::|:.::||.......|..    :.|..||..||:::
Frog   544 IKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISPETVHTTRLYGLSTFKDARHSAEEEI 608

  Fly   570 GLRICSKIDEFFELSAYDWLLVEPPGIASAFITDMISYLKSTFDSFAFKLPH-----------IA 623
            ..::..|||||.:|:.|||.:.||.|.||.::.|:|::|:|||..|. .||:           :|
Frog   609 YTKLNQKIDEFIQLADYDWTMSEPDGRASGYLMDLINFLRSTFQVFT-NLPNNSNDHAAMSGKVA 672

  Fly   624 QAACRRTFEHIAEKIYSIMYDEDVKQISTGALTQINLDLMQCEFFAASEPVPGLKEGELSKYFLR 688
            |.||....:|::..:..::.|.|:||||.||:.|.|||::|||.||:|:||||.:|..|...|:.
Frog   673 QTACMSACKHLSTSLTQMLLDSDLKQISMGAIQQFNLDVIQCELFASSDPVPGFQEDTLQLAFID 737

  Fly   689 NRQLLDLLILEEWSTYFHDYGKQENRYHLVQPQSIIVILEKIREADKK-PIFSLVRKN--DKKKL 750
            .||||||.::.:||.|..|||:..::|..|.|.:.:::|||::::.|| .|||..|||  ||:||
Frog   738 LRQLLDLFMVWDWSAYLADYGQPYSKYLRVNPSTALILLEKMKDSSKKNNIFSQFRKNDRDKQKL 802

  Fly   751 LETVLKQLKHIAD 763
            :|||:|||:.:.:
Frog   803 IETVVKQLRSLVN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec15	NP_650942.1	Sec15	428..730	CDD:282011	132/316 (42%)
exoc6	XP_031761799.1	Sec15	463..779	CDD:397972	132/316 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I1161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I871
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103153at33208
OrthoFinder	1	1.000	-	-		FOG0002120
OrthoInspector	1	1.000	-	-		otm47673
Panther	1	1.100	-	-	O	PTHR12702
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160