DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d22 and TBC1D4

DIOPT Version :10

Sequence 1:NP_650941.3 Gene:Tbc1d22 / 42498 FlyBaseID:FBgn0038855 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_055647.2 Gene:TBC1D4 / 9882 HGNCID:19165 Length:1298 Species:Homo sapiens


Alignment Length:560 Identity:106/560 - (18%)
Similarity:194/560 - (34%) Gaps:171/560 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 TFWKNSGRRVPGRPSPKRELEKAAAVGVAVGRGAAPGSGMVSTFTEYQKSV--SDAWDMGDDEFC 113
            :|::||||..|                                  :|:..:  ..|.:..|.|..
Human   716 SFYQNSGRLSP----------------------------------QYENEIRQDTASESSDGEGR 746

  Fly   114 IISSTEAAAAAVGAGDAAHFSRQVS--QTVALNVIETHSRSNQNHNASRSANESGAD---LVPVS 173
            ..:|:..:..::..|..:...|::|  |.:.|.|     .|..|.:.|....:.|.|   |:|:|
Human   747 KRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV-----ASPMNKSPSAMQQQDGLDRNELLPLS 806

  Fly   174 S--------------SSTDDCK--EDRRSLPDSNENRSRLRNYPGRP----QLQKISSNCQDSEY 218
            .              |..||.:  |:|:.   |.|.||..|....:.    :::|.:...:.|..
Human   807 PLSPTMEEEPLVVFLSGEDDPEKIEERKK---SKELRSLWRKAIHQQILLLRMEKENQKLEASRD 868

  Fly   219 ETKIEKFQVVLDSPQLDLVALKK---ISW-----------------------SGVPRKMRAVSWR 257
            |.:..|  |.||..::.  |.:|   |:|                       .|||:..|...|:
Human   869 ELQSRK--VKLDYEEVG--ACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQ 929

  Fly   258 LLSKYLPPSSERRMAVLESKRQGYQDLRHNYFRVDSQDETQQDTYRQ-----------IHIDVPR 311
            .|:             |:.:      |||   |:.::.:....:|::           |.:|:.|
Human   930 FLA-------------LQYR------LRH---RLPNKQQPPDISYKELLKQLTAQQHAILVDLGR 972

  Fly   312 MNPQIPLFQQQL--VQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYD 374
            ..|..|.|..||  .|.....:|..:::.....||.|||:.:.....:...:|..........||
Human   973 TFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYD 1037

  Fly   375 MSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGV 439
            :.                        .:..|....:.:|.::.||..|:.....:|:.||:.:.:
Human  1038 LG------------------------FRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078

  Fly   440 DYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVCAAFLLHWKEQL-MQQNDFQG 503
            ....::..|...|...:..|....|::|....:....    ::..|..||..:|.| |:...|:.
Human  1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEV----IFKVALSLLSSQETLIMECESFEN 1139

  Fly   504 LMLLLQN-LPTHNWSDRQINVLLAEAFRLKFTYADAPKHL 542
            ::..|:| ||..|.|  ::..::.:.|.:     |..|.|
Human  1140 IVEFLKNTLPDMNTS--EMEKIITQVFEM-----DISKQL 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d22NP_650941.3 TBC 243..496 CDD:214540 49/289 (17%)
TBC1D4NP_055647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
PTB 31..190 CDD:214675
PTB_TBC1D1_like 193..437 CDD:269967
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..287
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 586..685
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..765 7/73 (10%)
DUF3350 801..864 CDD:463365 14/65 (22%)
TBC 918..1132 CDD:214540 48/263 (18%)
COG4372 1161..>1267 CDD:443500 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

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