DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5745 and GYP1

DIOPT Version :9

Sequence 1:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_014713.1	Gene:	GYP1 / 854236	SGDID:	S000005596	Length:	637	Species:	Saccharomyces cerevisiae

Alignment Length:	637	Identity:	216/637 - (33%)
Similarity:	290/637 - (45%)	Gaps:	161/637 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TAESTAAATGTAGAGVAVVTVASGAGPTPGANSSTFWKN--SGRRVPGRPSPKRELEKAAAVGVA 79
            |.|||:..:|.|.:       |.....|...|.....|.  |.||.....||.|.:.  ..:..|
Yeast    48 TTESTSLPSGYASS-------ADRDRRTSDGNFEAMAKQQASTRRTSNSYSPLRYVN--PTLSTA 103

  Fly    80 VGRGAAP--------------------GSGMV----STFTEYQKSVSDAW--DMGDDEFCIISST 118
            ......|                    .||.|    |..||..|. .|.:  |:.:|...:|...
Yeast   104 SNESPRPALLLRQHHQRHHHHQQPRHSSSGSVGNNCSNSTEPNKK-GDRYFKDLDEDWSAVIDDY 167

  Fly   119 EAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASRSANESGADLVPVSSSSTDDCKED 183
            ......:..|.   |...|:.|..|:...|.|..|       |.:..|...|..||||.
Yeast   168 NMPIPILTNGG---FGTPVAPTRTLSRKSTSSSIN-------SISNMGTSAVRNSSSSF------ 216

  Fly   184 RRSLPDSNENRSRLRNYPGRPQLQKISSNCQDS-----EYET------------KIEKFQVVL-D 230
                           .||..|||||..:|  ||     |.|.            :|.||..:| |
Yeast   217 ---------------TYPQLPQLQKEKTN--DSKKTQLEIENERDVQELNSIIQRISKFDNILKD 264

  Fly   231 SPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAVLESKRQGYQD-LRHNYFRVDSQ 294
            ...::...|::|||:|:|:..|.|.|:||..|||.:::|:...|:.||:.|:| |:|.:     .
Yeast   265 KTIINQQDLRQISWNGIPKIHRPVVWKLLIGYLPVNTKRQEGFLQRKRKEYRDSLKHTF-----S 324

  Fly   295 DETQQD--TYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVTPFFI 357
            |:..:|  |:.||.||:||.||.|||:|.:.||...:|||::||||||||||||||||||||||.
Yeast   325 DQHSRDIPTWHQIEIDIPRTNPHIPLYQFKSVQNSLQRILYLWAIRHPASGYVQGINDLVTPFFE 389

  Fly   358 VFLQEALTPN--TDLEKYDMST-LPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQL 419
            .||.|.|.|:  .|:|..|.|| :.:|....:|||:||||:|.|:.|.||||..|.||..:|..|
Yeast   390 TFLTEYLPPSQIDDVEIKDPSTYMVDEQITDLEADTFWCLTKLLEQITDNYIHGQPGILRQVKNL 454

  Fly   420 KDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAE------------ 472
            ..|::|||.:|:.|.|...|:::||:|||||.||.||..:...||:|||||:|
Yeast   455 SQLVKRIDADLYNHFQNEHVEFIQFAFRWMNCLLMREFQMGTVIRMWDTYLSETSQEVTSSYSMS 519

  Fly   473 --------------------------SDGFAL----------------------FHLYVCAAFLL 489
                                      |...||                      ||::||||||:
Yeast   520 SNDIKPPVTPTEPRVASFVTPTKDFQSPTTALSNMTPNNAVEDSGKMRQSSLNEFHVFVCAAFLI 584

  Fly   490 HWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAFRLKFTYADAPKH 541
            .|.:|||:. |||..:..|||.||.:|::..|.:||:|||..:..|.||..|
Yeast   585 KWSDQLMEM-DFQETITFLQNPPTKDWTETDIEMLLSEAFIWQSLYKDATSH 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	132/318 (42%)
GYP1	NP_014713.1	COG5210	24..632	CDD:227535	213/632 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346284
Domainoid	1	1.000	220	1.000	Domainoid score	I458
eggNOG	1	0.900	-	-		E1_KOG1092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I471
Isobase	1	0.950	-	0	Normalized mean entropy	S1237
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002429
OrthoInspector	1	1.000	-	-		oto99666
orthoMCL	1	0.900	-	-		OOG6_101452
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R539
SonicParanoid	1	1.000	-	-		X1614
TreeFam	1	0.960	-	-
	14	13.730