DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d22 and TBC1D17

DIOPT Version :10

Sequence 1:NP_650941.3 Gene:Tbc1d22 / 42498 FlyBaseID:FBgn0038855 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_078958.2 Gene:TBC1D17 / 79735 HGNCID:25699 Length:648 Species:Homo sapiens


Alignment Length:329 Identity:82/329 - (24%)
Similarity:128/329 - (38%) Gaps:80/329 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 RSLPDSNENRSRLRNYPGRPQLQKISSNCQDSEYETKIEKFQVVLDSPQLDLVALK----KISWS 245
            |..|.:.|..:|.....||  ||::.        |.|...|...| ||.|...|.|    .:||.
Human   277 RGPPVTEEEWARHVGPEGR--LQQVP--------ELKNRIFSGGL-SPSLRREAWKFLLGYLSWE 330

  Fly   246 GVPRKMRA-------------VSWRLLSKYLPPSSERRMAVLESKRQGYQDLRHNYFRVDSQDET 297
            |...:.:|             :.|:.:|    |..|||.::|           |.|..:..:|.:
Human   331 GTAEEHKAHIRKKTDEYFRMKLQWKSVS----PEQERRNSLL-----------HGYRSLIERDVS 380

  Fly   298 QQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQE 362
            :.|...:.: :.|. ||.:.|...         ||..:.:.|...|||||::||::|...|... 
Human   381 RTDRTNKFY-EGPE-NPGLGLLND---------ILLTYCMYHFDLGYVQGMSDLLSPILYVIQN- 433

  Fly   363 ALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQLKDLIQRID 427
                                    |.|:|||...|::.:|.|:..:|..::.::.:|..|::.:|
Human   434 ------------------------EVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLD 474

  Fly   428 VNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVCAAFLLHWK 492
            ..|...|.:.....|.|.|||:.....||.|....:|||:.......|..| ||.|..|.|...:
Human   475 PLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNL-HLLVACAILDMER 538

  Fly   493 EQLM 496
            :.||
Human   539 DTLM 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d22NP_650941.3 TBC 243..496 CDD:214540 63/265 (24%)
TBC1D17NP_078958.2 PH_RBD 7..205 CDD:432305
Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040 218..309 11/41 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..259
TBC 307..542 CDD:214540 70/287 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..648
Blue background indicates that the domain is not in the aligned region.

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