DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5745 and tbc1d22a

DIOPT Version :9

Sequence 1:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_017947794.1	Gene:	tbc1d22a / 733870	XenbaseID:	XB-GENE-5866746	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	237/540 - (43%)
Similarity:	320/540 - (59%)	Gaps:	77/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ANSSTFWKNSGRRVPG---------------------------RPSPKRELEKAAAVGVAVGRGA 84
            |....||:.:..||||                           .|:...:|:|
Frog     5 AGRKQFWRRNVSRVPGSIQHVYGAQHPPFDPQLHGTLTKSVLKHPTTPVKLKK------------ 57

  Fly    85 APGSGMVSTFTEYQKSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETH 149
                  .:||.|::.:.|||||:|:|:      .|..|.|     |.:.:..|....|..||:.|
Frog    58 ------TTTFQEFESNTSDAWDVGEDD------DELLAMA-----AENLNSNVVMETAKQVIQNH 105

  Fly   150 SR--SNQNHNASRSANESGADLVPVSSSSTDDCK----EDRRSLPDSNENRSRLRNYPGRPQL-- 206
            ::  ....|.||:...||.. |....|.|:.:.|    ....|:|..:..:..|:.....||.
Frog   106 TKLQEQSKHQASQQEEESFV-LDETQSLSSHENKIGKSASESSIPKISGEKHTLQRQQSVPQQTS 169

  Fly   207 ---------QKISSNCQDSEYET-KIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSK 261
                     |.||...:.:|.|. ::|||:.:|..|..||..|:|:||||||:.:|:::|:||:.
Frog   170 IPVMLKMADQAISCGSELNEREAFRVEKFKQLLAGPNTDLDELRKLSWSGVPKSVRSITWKLLTG 234

  Fly   262 YLPPSSERRMAVLESKRQGYQDLRHNYFRVDSQDETQQDTYRQIHIDVPRMNPQIPLFQQQLVQE 326
            |||.:.|||.:.|:.|::.|......|:. ...|:|.|.||||||||||||:|: .|..|.:|.|
Frog   235 YLPANVERRESTLKRKQKEYFAFIEQYYS-SRNDDTNQSTYRQIHIDVPRMSPE-SLILQPVVTE 297

  Fly   327 MFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSF 391
            :|||||||||||||||||||||||||||||:|||.:.:....::|..|:|:||||....|||||:
Frog   298 VFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSDYIDEEVEVENADVSSLPEEVLRNIEADSY 362

  Fly   392 WCLSKFLDCIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRE 456
            ||:||.||.|||||.|||.|||.||..|::|:.|||..:|.|||.:.|:||||:||||||||.||
Frog   363 WCMSKLLDGIQDNYTFAQPGIQRKVKMLEELVSRIDDQVHSHLQQYEVEYLQFAFRWMNNLLMRE 427

  Fly   457 LPLHCTIRLWDTYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQI 521
            |||.|||||||||.:|.:||:.||||||||||:.|::.::::.||.||::.||||||.:|.|..:
Frog   428 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLVRWRKDILEEKDFHGLLIFLQNLPTEHWKDEDM 492

  Fly   522 NVLLAEAFRLKFTYADAPKH 541
            :||||||:||||.:||||.|
Frog   493 SVLLAEAYRLKFAFADAPNH 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	153/252 (61%)
tbc1d22a	XP_017947794.1	RabGAP-TBC	276..467	CDD:366170	127/191 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1219
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1650
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220411at33208
OrthoFinder	1	1.000	-	-		FOG0002429
OrthoInspector	1	1.000	-	-		otm48602
Panther	1	1.100	-	-	O	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R539
SonicParanoid	1	1.000	-	-		X1614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190