Protein Alignment Tbc1d22 and TBC1D15

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: XP_006719627.1
• Gene: TBC1D15 / 64786
• HGNCID: 25694
• Length: 699
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 85/352 - (24%)
• Similarity: 155/352 - (44%)
• Gaps: 68/352 - (19%)

  Fly   203 RPQLQKISSNCQDSEYETKIEKFQVVLDSPQ--LDLVALKKISW-SGVPRKMRAVSWRLLSKYLP 264
            ||.:|:        .....:|::...:||..  |::..:|::.: .|:...:|..:|:.|..|.|
Human   316 RPVVQR--------REPVSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFP 372

  Fly   265 PSSERRMAVLESKRQGYQDLRHNYFRVD------SQDETQQDT----YRQ-IHIDVPRMNPQIPL 318
            ..|.:     |.:.|..:.....|||:.      ||::.::::    ||. |..||.|.:.....
Human   373 WDSTK-----EERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKF 432

  Fly   319 FQQQ----LVQEMFERILFIWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLP 379
            ::.|    |:  :...||..:.:.....|||||::||::|...|           :|.
Human   433 YEGQDNPGLI--LLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV-----------MEN------- 477

  Fly   380 EETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQF 444
                   |.|:|||.:.::|.:..|:.....|::.::.||..|::.:|.....:|::....||.|
Human   478 -------EVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYF 535

  Fly   445 SFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQ 509
            .|||:.....||......:|||:....|.. ...|||.:|.|.|...|:|:|:::  .|...:|:
Human   536 CFRWLLIRFKREFSFLDILRLWEVMWTELP-CTNFHLLLCCAILESEKQQIMEKH--YGFNEILK 597

  Fly   510 NLPTHNWSDRQINV----LLAEAFRLK 532
            ::   |....:|:|    ..|||..|:
Human   598 HI---NELSMKIDVEDILCKAEAISLQ 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	67/268 (25%)
TBC1D15	XP_006719627.1	PH_RBD	19..219	CDD:432305
		TBC	351..586	CDD:214540	67/267 (25%)