Protein Alignment Tbc1d22 and tbc1d22b

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: XP_009302051.1
• Gene: tbc1d22b / 557377
• ZFINID: ZDB-GENE-091118-28
• Length: 516
• Species: Danio rerio
• Alignment Length: 533
• Identity: 244/533 - (45%)
• Similarity: 330/533 - (61%)
• Gaps: 63/533 - (11%)

  Fly    48 NSSTFWKNSGRRVPG----------------RPSPKRELEKAAAVGVAVGRGAAPGSGMVSTFTE 96
            |...||:.: .:|||                |..|.::..||::|         ..|...|||.|
Zfish     5 NRIHFWRKN-PKVPGSLQPVYGAQHPPLDPRRHRPLKDTPKASSV---------VKSKKPSTFHE 59

  Fly    97 YQKSVSDAWDMGDDE-FCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIE--------THSRS 152
            :.:|.:||||:.|:| ..|.|..:::::.|.       ||...||..|.:.:        |.|..
Zfish    60 FARSTNDAWDIDDEEDDGIFSLKQSSSSPVQ-------SRSTPQTPCLKLFKVPDDTELGTRSLD 117

  Fly   153 NQ-----NHNASRSANESGADLVPVSSSSTDDCKEDRRSLPDSNENRSRLRNYPGRPQLQKIS-- 210
            .|     |.:..|...|||    |.:......|.:.:.::..:.....:.::.|.||.:..::
Zfish   118 RQEPISTNPDQERLDVESG----PANGRVVKSCSDAQLNVNTARNPLQKQQSLPVRPVIPLVARI 178

  Fly   211 --SNCQDS-----EYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSE 268
              .|...:     ..:|:::||:.:|.|...||..|:|.||||:||::|.|:|||||.|||.:.|
Zfish   179 SDQNASGAPPMTVREKTRLDKFKQLLSSSNTDLEELRKHSWSGIPREVRPVTWRLLSGYLPANRE 243

  Fly   269 RRMAVLESKRQGYQDLRHNYFRVDSQDETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILF 333
            ||..||:.||:.|......|:. ...||..:|||||||||:||.||.||||||.||||:||||||
Zfish   244 RRDLVLQRKREEYFGFIEQYYH-SRTDENHRDTYRQIHIDIPRTNPLIPLFQQPLVQEVFERILF 307

  Fly   334 IWAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFL 398
            |||||||||||||||||||||||:|||.|.:  ..|:|.::|::||.:|:..||||||||:||.|
Zfish   308 IWAIRHPASGYVQGINDLVTPFFVVFLSEFV--EEDVENFEMASLPLDTQRNIEADSFWCMSKLL 370

  Fly   399 DCIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTI 463
            |.|||||.|||.|||.||..|::|:.|||.::|.|.|...|:||||:||||||||.|||||.|||
Zfish   371 DGIQDNYTFAQPGIQIKVKALEELVSRIDEDVHVHFQKCEVEYLQFAFRWMNNLLMRELPLRCTI 435

  Fly   464 RLWDTYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEA 528
            ||||||.|||:||:.||||||||||:.|:::::...|||.|::|||||||.:|.:.::.:|||||
Zfish   436 RLWDTYQAESEGFSHFHLYVCAAFLIKWRKEILSMLDFQNLLMLLQNLPTIHWGNEEVGLLLAEA 500

  Fly   529 FRLKFTYADAPKH 541
            :|||:.:||||.|
Zfish   501 YRLKYMFADAPSH 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	165/252 (65%)
tbc1d22b	XP_009302051.1	TBC	218..468	CDD:214540	165/252 (65%)