Protein Alignment Tbc1d22 and TBC1D22B

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_060242.2
• Gene: TBC1D22B / 55633
• HGNCID: 21602
• Length: 505
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 248/529 - (46%)
• Similarity: 334/529 - (63%)
• Gaps: 66/529 - (12%)

  Fly    48 NSSTFWKNSGRRVPGRPSP--------------KRELEKAAAVGVAVGRGAAPGSGMVSTFTEYQ 98
            ||..|||.|. ::||...|              |..:::.:.|.....:     :...|:|.|:.
Human     5 NSKQFWKRSA-KLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLK-----NKKASSFHEFA 63

  Fly    99 KSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASRS-- 161
            ::.|||||:||||....||.....          .:.:|:...|..|:|.||:.......|:|
Human    64 RNTSDAWDIGDDEEEDFSSPSFQT----------LNSKVALATAAQVLENHSKLRVKPERSQSTT 118

  Fly   162 ----AN----ESGADLVPVSSSSTDDCKED----RRSLPDSNENRSRLRNYPGRPQLQKIS-SNC 213
                ||    :|.:| ..:|.:|:|.|..:    ::|||        ||  |..|.:.:|| .|.
Human   119 SDVPANYKVIKSSSD-AQLSRNSSDTCLRNPLHKQQSLP--------LR--PIIPLVARISDQNA 172

  Fly   214 QDS-----EYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAV 273
            ..:     ..:|::|||:.:|.|...||..|:|.||.||||::|.::|||||.|||.::|||...
Human   173 SGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLT 237

  Fly   274 LESKRQGYQDLRHNYFRVDSQ-DETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAI 337
            |:.||:.|......|:  ||: :|..||||||||||:||.||.||||||.||||:||||||||||
Human   238 LQRKREEYFGFIEQYY--DSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 300

  Fly   338 RHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQ 402
            |||||||||||||||||||:|||.|.:  ..|:|.:|::.|.::....||||||||:||.||.||
Human   301 RHPASGYVQGINDLVTPFFVVFLSEYV--EEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQ 363

  Fly   403 DNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWD 467
            |||.|||.|||:||..|::|:.|||..:|.|.:.:.|:||||:||||||||.|||||.|||||||
Human   364 DNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWD 428

  Fly   468 TYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAFRLK 532
            ||.:|.:||:.||||||||||:.|:::::.:.|||||::|||||||.:|.:.:|.:|||||:|||
Human   429 TYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLK 493

  Fly   533 FTYADAPKH 541
            :.:||||.|
Human   494 YMFADAPNH 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	160/253 (63%)
TBC1D22B	NP_060242.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..146		11/41 (27%)
		TBC	207..457	CDD:214540	160/253 (63%)