DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tbc1d22 and TBC1D2

DIOPT Version :10

Sequence 1:NP_650941.3 Gene:Tbc1d22 / 42498 FlyBaseID:FBgn0038855 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_001254500.1 Gene:TBC1D2 / 55357 HGNCID:18026 Length:928 Species:Homo sapiens


Alignment Length:388 Identity:95/388 - (24%)
Similarity:146/388 - (37%) Gaps:72/388 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 ANESGADLVPVSSSSTDDCKEDRRSLPDSNENRSRLRNYPGRPQLQKISSNCQDSEYETKIEKFQ 226
            |.|:.:|.:.:|..|..| :....::||......:|        |.||.:....|.:...:|   
Human   544 AGEASSDSIELSPISKYD-EYGFLTVPDYEVEDLKL--------LAKIQALESRSHHLLGLE--- 596

  Fly   227 VVLDSPQL-------DLV---ALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAVLESKRQG- 280
             .:|.|..       |||   .||::..:||||:.|...||.|.         .:.|......| 
Human   597 -AVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLV---------HLRVQHLHTPGC 651

  Fly   281 YQDLRHNYFRVDSQDETQQDTYRQIHIDVPRMNPQIPLF--QQQLVQEMFERILFIWAIRHPASG 343
            ||:|      :......:....|||.:|:.|..|....|  ......:...|:|..::.::|..|
Human   652 YQEL------LSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIG 710

  Fly   344 YVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQ--DNYI 406
            |.||:|.|.....:| |:|                        |..:||||...::.|.  |.|.
Human   711 YCQGLNRLAAIALLV-LEE------------------------EESAFWCLVAIVETIMPADYYC 750

  Fly   407 FAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLA 471
            ......|.....|:||:......|..||..|.||....:|.|...:....|..:..:|:||.:|.
Human   751 NTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLY 815

  Fly   472 ESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAE--AFRLK 532
            |  |..:...|..|.|..:.||.|..||..:....|.....|.:.|.:.:|:...:  .||:|
Human   816 E--GTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMK 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tbc1d22NP_650941.3 TBC 243..496 CDD:214540 64/257 (25%)
TBC1D2NP_001254500.1 SMC_prok_B <276..480 CDD:274008
Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244 295..433
TBC 625..837 CDD:214540 64/253 (25%)
Interaction with CADH1 1..169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
PH_TBC1D2A 47..147 CDD:269966
Atrophin-1 <183..>292 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..275
Blue background indicates that the domain is not in the aligned region.

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