Protein Alignment Tbc1d22 and Tbc1d22b

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_001020230.1
• Gene: Tbc1d22b / 502414
• RGDID: 1564987
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 250/532 - (46%)
• Similarity: 334/532 - (62%)
• Gaps: 72/532 - (13%)

  Fly    48 NSSTFWKNSGRRVPGRPSPK-----------------RELEKAAAVGVAVGRGAAPGSGMVSTFT 95
            ||..|||.|. ::||...|.                 :|..|..:|.:.        :...|:|.
  Rat     5 NSKQFWKRSA-KLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNSVPLK--------NKKASSFH 60

  Fly    96 EYQKSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASR 160
            |:.::.|||||:||||...:||.....          .:.:|:...|..|:|.||:.......|:
  Rat    61 EFARNTSDAWDIGDDEEEDLSSPSLQT----------LNSKVALATAAQVLENHSKLRVKPERSQ 115

  Fly   161 S------AN----ESGADLVPVSSSSTDDCKED----RRSLPDSNENRSRLRNYPGRPQLQKIS- 210
            |      ||    :|.:| ..:|.:|:|.|..:    ::|||        ||  |..|.:.:||
  Rat   116 STTSDVPANYKVIKSSSD-AQLSRNSSDTCLRNTLHKQQSLP--------LR--PIIPLVARISD 169

  Fly   211 SNCQDS-----EYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERR 270
            .|...:     ..:|::|||:.:|.|...||..|:|.||.||||::|.|:|||||.|||.::|||
  Rat   170 QNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKWSWPGVPREVRPVTWRLLSGYLPANTERR 234

  Fly   271 MAVLESKRQGYQDLRHNYFRVDSQ-DETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFI 334
            ...|:.||:.|......|:  ||: :|..||||||||||:||.||.||||||.||||:|||||||
  Rat   235 KLTLQRKREEYFGFIEQYY--DSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFI 297

  Fly   335 WAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLD 399
            ||||||||||||||||||||||:|||.|.:  ..|:|.:|::.|.::....||||||||:||.||
  Rat   298 WAIRHPASGYVQGINDLVTPFFVVFLSEYV--EEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 360

  Fly   400 CIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIR 464
            .|||||.|||.|||:||..|::|:.|||..:|.|.:.:.|:||||:||||||||.|||||.||||
  Rat   361 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHSHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIR 425

  Fly   465 LWDTYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAF 529
            |||||.:|.:||:.||||||||||:.|:::::.:.|||||::|||||||.:|.:.:|.:|||||:
  Rat   426 LWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAY 490

  Fly   530 RLKFTYADAPKH 541
            |||:.:||||.|
  Rat   491 RLKYMFADAPNH 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	161/253 (64%)
Tbc1d22b	NP_001020230.1	TBC	207..457	CDD:214540	161/253 (64%)