DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5745 and CG12241

DIOPT Version :9

Sequence 1:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	98/497 - (19%)
Similarity:	164/497 - (32%)	Gaps:	168/497 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VTVASGAGPTPG----ANSSTFWKNSGRRVPGRPSPKRELEKAAAVGVAVGRGAAPGSGMVSTFT 95
            ::||.|..|.||    |.:::.|            |:..|.|       :|.||...||
  Fly    44 LSVADGLRPNPGGPFSALTASMW------------PQEILAK-------LGGGAELASG------ 83

  Fly    96 EYQKSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASR 160
                 .:|..:...|||                                             ..|
  Fly    84 -----PNDQPEYRFDEF---------------------------------------------GFR 98

  Fly   161 SANESGADLVPVSSSSTDDCKEDRRSLPDSNENRSRLRNYPGRPQLQKISSNCQDSEYETKIEKF 225
            ...|.|    |..||:      ...|:|...:.:.||:      .:..:..:......|...|..
  Fly    99 VEEEDG----PEQSSN------KLLSIPFVEDAQQRLQ------WIAHLEFSHNKEAAELSWEHV 147

  Fly   226 QVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAVLESKRQGYQDLRHNYFR 290
            .|:|  |:.:  .|:.:...|:|..:||..|..||..|            :|:|..:...|:..:
  Fly   148 DVML--PRTE--KLRNMVRQGIPHTLRAQMWMRLSGAL------------AKKQKSETSYHDIVK 196

  Fly   291 VDSQDETQQDTYRQIHIDVPRM--------NPQ---IPLFQQQLVQEMFERILFIWAIRHPASGY 344
            ..|.|:..  |.:||..|:.|:        ||.   ||         ...|||...|...|..||
  Fly   197 ASSNDQLM--TSKQIEKDLLRILPTNACFSNPNGTGIP---------RLRRILRGIAWLFPDIGY 250

  Fly   345 VQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFL-DCIQDNYIFA 408
            .|| ..::....::|::                         |.::||.::..: |.:..:|..:
  Fly   251 CQG-TGVIVACLLLFME-------------------------EENAFWMMATIVEDLLPASYYSS 289

  Fly   409 Q-LGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAE 472
            . ||||.....:..||.....::...|:.|.::....:..|...|....:.:...:|:||.:..|
  Fly   290 TLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYE 354

  Fly   473 SDGFALFHLYVCAAFLLHWKEQLMQ--QNDFQGLMLLLQNLP 512
            . ...||.|   ...:|..|||.::  :|..| :...|.::|
  Fly   355 G-SIVLFQL---TLGMLKVKEQDLKHLENSAQ-IFNSLSDIP 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	58/265 (22%)
CG12241	NP_650432.1	TBC	161..375	CDD:214540	58/266 (22%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940