DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5745 and tbc1d22a

DIOPT Version :9

Sequence 1:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_999964.1	Gene:	tbc1d22a / 407720	ZFINID:	ZDB-GENE-041114-144	Length:	567	Species:	Danio rerio

Alignment Length:	577	Identity:	255/577 - (44%)
Similarity:	335/577 - (58%)	Gaps:	101/577 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NSSTFWKNSGRRVPGR-------------PSPKRELEKAAAVGVAVGRGAAPGS-GMVSTFTEYQ 98
            |...|||.:..:|||.             |.....|.||   |......:.||. ...:||.|::
Zfish     6 NKKQFWKRNTAKVPGNIQHVYGAQHPPFDPLLHANLMKA---GNKPPSASTPGKPKKATTFQEFE 67

  Fly    99 KSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHS----RSNQNHNAS 159
            ...|||||:|||:      .|..|.|     |.:.:.:|....|..|||.||    |..|....:
Zfish    68 SITSDAWDVGDDD------DELLAMA-----AQNLNIEVVMETANKVIENHSKLQERRQQEMEKT 121

  Fly   160 RSANESGADLVPVSSSSTDDCKE--------------DRRSLPDSNENRS--------------- 195
            ...:|...:.|.......::.:|              |...|.||...:|
Zfish   122 TEPDEKYGEEVEEEEEEPEEEEEREEVVETTDVSFSTDPLPLGDSRLVKSHSEAPIGSPKEVGIK 186

  Fly   196 -----RLRNYPGRPQL--------QKISSNCQDSEYE-TKIEKFQVVLDSPQLDLVALKKISWSG 246
                 |.::.|.||.:        |..|.....:|.| ::::||:.||..|..||..|:|:||||
Zfish   187 QAALHRQQSLPHRPVIPLVARMADQNTSGTPAMTEREASRLDKFRQVLAGPNTDLEELRKLSWSG 251

  Fly   247 VPRKMRAVSWRLLSKYLPPSSERRMAVLESKRQGYQDLRHNYFRVDSQ-DETQQDTYRQIHIDVP 310
            :||::|.::|:|||.|||.::|||.:.|:.|||.|......|:  ||: ||..||||||||||:|
Zfish   252 IPRQVRPITWKLLSGYLPANAERRESTLQRKRQEYFGFIEQYY--DSRNDEHHQDTYRQIHIDIP 314

  Fly   311 RM---------------------NPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVTP 354
            ||                     ||.||||||..|||:|||||||||||||||||||||||||||
Zfish   315 RMSPESLVLQPKVTEIHIDIPRTNPLIPLFQQASVQEIFERILFIWAIRHPASGYVQGINDLVTP 379

  Fly   355 FFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQLGIQEKVNQL 419
            ||:|::.|.:  ..::|.:::|:|.||....||||||||:||.||.|||||.|||.|||.||..|
Zfish   380 FFVVYVFEYI--EEEVENFNVSSLQEEVLRNIEADSFWCMSKLLDGIQDNYTFAQPGIQRKVKAL 442

  Fly   420 KDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYLAESDGFALFHLYVC 484
            ::|:.|||..:|||:|.:.|:||||:||||||||.|||||.|||||||||.||.:||:.||||||
Zfish   443 EELVSRIDETVHRHMQLYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQAEPEGFSHFHLYVC 507

  Fly   485 AAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAFRLKFTYADAPKH 541
            ||||:.|:::::::.||||||:|||||||.:|.:.:::||||||:||||.:||||.|
Zfish   508 AAFLVRWRKEILEEKDFQGLMILLQNLPTMHWGNEEVSVLLAEAYRLKFAFADAPNH 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	163/274 (59%)
tbc1d22a	NP_999964.1	TBC	248..519	CDD:214540	163/274 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	328	1.000	Domainoid score	I1145
eggNOG	1	0.900	-	-		E1_KOG1092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1702
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220411at33208
OrthoFinder	1	1.000	-	-		FOG0002429
OrthoInspector	1	1.000	-	-		otm26450
orthoMCL	1	0.900	-	-		OOG6_101452
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R539
SonicParanoid	1	1.000	-	-		X1614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860