DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5745 and Tbc1d22b

DIOPT Version :9

Sequence 1:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_941049.1	Gene:	Tbc1d22b / 381085	MGIID:	2681867	Length:	505	Species:	Mus musculus

Alignment Length:	532	Identity:	250/532 - (46%)
Similarity:	333/532 - (62%)	Gaps:	72/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NSSTFWKNSGRRVPGRPSPK-----------------RELEKAAAVGVAVGRGAAPGSGMVSTFT 95
            ||..|||.|. ::||...|.                 :|..|..:|.:.        :...|:|.
Mouse     5 NSKQFWKRSA-KLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNSVPLK--------NKKASSFH 60

  Fly    96 EYQKSVSDAWDMGDDEFCIISSTEAAAAAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASR 160
            |:.::.|||||:||||....||.....          .:.:|:...|..|:|.||:.......|:
Mouse    61 EFARNTSDAWDIGDDEEEDFSSPPFQT----------LNSKVALATAAQVLENHSKLRVKPERSQ 115

  Fly   161 S------AN----ESGADLVPVSSSSTDDCKED----RRSLPDSNENRSRLRNYPGRPQLQKIS- 210
            |      ||    :|.:| ..:|.:|:|.|..:    ::|||        ||  |..|.:.:||
Mouse   116 STTSDVPANYKVIKSSSD-AQLSRNSSDTCLRNPLHKQQSLP--------LR--PIIPLVARISD 169

  Fly   211 SNCQDS-----EYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERR 270
            .|...:     ..:|::|||:.:|.|...||..|:|.||.||||::|.|:|||||.|||.::|||
Mouse   170 QNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKWSWPGVPREVRPVTWRLLSGYLPANTERR 234

  Fly   271 MAVLESKRQGYQDLRHNYFRVDSQ-DETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFI 334
            ...|:.||:.|......|:  ||: :|..||||||||||:||.||.||||||.||||:|||||||
Mouse   235 KLTLQRKREEYFGFIEQYY--DSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFI 297

  Fly   335 WAIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLD 399
            ||||||||||||||||||||||:|||.|.:  ..|:|.:|::.|.::....||||||||:||.||
Mouse   298 WAIRHPASGYVQGINDLVTPFFVVFLSEYV--EEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 360

  Fly   400 CIQDNYIFAQLGIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIR 464
            .|||||.|||.|||:||..|::|:.|||..:|.|.:.:.|:||||:||||||||.|||||.||||
Mouse   361 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHSHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIR 425

  Fly   465 LWDTYLAESDGFALFHLYVCAAFLLHWKEQLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAF 529
            |||||.:|.:||:.||||||||||:.|:::::.:.|||||::|||||||.:|.:.:|.:|||||:
Mouse   426 LWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAY 490

  Fly   530 RLKFTYADAPKH 541
            |||:.:||||.|
Mouse   491 RLKYMFADAPNH 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5745	NP_650941.3	TBC	243..496	CDD:214540	161/253 (64%)
Tbc1d22b	NP_941049.1	TBC	207..457	CDD:214540	161/253 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1212
eggNOG	1	0.900	-	-		E1_KOG1092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23043
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1675
Isobase	1	0.950	-	0	Normalized mean entropy	S1237
OMA	1	1.010	-	-		QHG54276
OrthoDB	1	1.010	-	-		D220411at33208
OrthoFinder	1	1.000	-	-		FOG0002429
OrthoInspector	1	1.000	-	-		otm43452
orthoMCL	1	0.900	-	-		OOG6_101452
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R539
SonicParanoid	1	1.000	-	-		X1614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820