Protein Alignment Tbc1d22 and Tbc1d8b

DIOPT Version :10

• Sequence 1: NP_650941.3
• Gene: Tbc1d22 / 42498
• FlyBaseID: FBgn0038855
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_001388066.1
• Gene: Tbc1d8b / 315912
• RGDID: 1563084
• Length: 1118
• Species: Rattus norvegicus
• Alignment Length: 535
• Identity: 107/535 - (20%)
• Similarity: 182/535 - (34%)
• Gaps: 155/535 - (28%)

  Fly   104 AWDMGDDEFCIISSTEAAAAAVGAGDAAHFS--RQVSQTVALNVIETHSRSNQNHNASRSANESG 166
            |.|..||      |:.:...::....|..|:  :...|.||...::..:.|.|         :.|
  Rat   348 AVDKTDD------SSRSVIISIKGKTAFRFNEVKDFEQLVAKLRLKCRAASTQ---------DDG 397

  Fly   167 ADLVPVSSSST---DDCKEDRRSLPDS---------------NENRSRLRNYPGRPQLQKISSNC 213
            :..|.:||.||   ::.:|...:.|..               .:|...|.:...:.::::.|.|.
  Rat   398 STEVAISSDSTGLSENFEEQPLTFPKECSKTVNTEALMTVFHPQNLENLDSKMLKEKMKEQSWNI 462

  Fly   214 QDSEYETKIEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAVLESKR 278
            ..||....:..|:.   ....|||.      .|:|..:|...|.|.|     .:...||.    .
  Rat   463 LFSECGRGVSMFRT---KKTRDLVV------RGIPETLRGELWMLFS-----GAVNDMAA----N 509

  Fly   279 QGYQDLRHNYFRVDSQD-ETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAIRHPAS 342
            .||      |..|..|. .|......:|..|:.|..|:.|.||.........|:|..:|.|:|..
  Rat   510 PGY------YAEVVEQSLGTSNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 568

  Fly   343 GYVQGINDLVTPFFIVFLQE-------------------------ALTPNTDLEKYDMSTLPEET 382
            ||.|.:| ::|...:::.:|                         ||......|:.....||:.|
  Rat   569 GYCQAMN-ILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLT 632

  Fly   383 RNIIEADSF------WCLSKFLDCIQDNYIFAQLGIQEKVN--------QLKDLIQR----IDVN 429
            .::.:...|      |.|:.|:         :.|.|:..||        .:|.::|.    :|.|
  Rat   633 DHMTDMTFFSSVSLSWFLTLFI---------SVLPIESAVNVVDCFFYDGIKAILQLGLAILDYN 688

  Fly   430 LHRHL----QAHGVDYLQFSFRWMNNLLTRELPL----------------HCTIRLWDTYLAESD 474
            |.:.|    .|..|..|.   |:.:|::.::.||                |..:.:.|.....::
  Rat   689 LDKLLTCKDDAEAVTALN---RFFDNVINKDSPLPSNVQQGSNINDGKSNHAKVDITDLIRESNE 750

  Fly   475 GFAL-----FHLYVC--AAFLLHWKEQLMQQNDF----QGLMLLLQNLPTHNWSDRQINVLLAEA 528
            .:..     .|...|  ..:::...|:..:||..    |.:.:.||.|      |....:...|.
  Rat   751 KYGSIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKMSLQEL------DELYVIFKKEL 809

  Fly   529 FRLKFTYADAP--KH 541
            |...:.|...|  ||
  Rat   810 FISCYWYLSCPGLKH 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d22	NP_650941.3	TBC	243..496	CDD:214540	64/323 (20%)
Tbc1d8b	NP_001388066.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	10/45 (22%)
		TBC	485..693	CDD:214540	51/232 (22%)